Evidence map›Paper›PMID 38871879›Full record

ArticleNeuroradiology2024

Cranial bone thickness and density anomalies quantified from CT images can identify chronic increased intracranial pressure.

Jiawei Liu, Jasmine Chaij, Marius George Linguraru, Brooke French, Robert Keating, Allyson L Alexander, Antonio R Porras

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Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Surgery for isolated sagittal synostosis: a neuro-developmental necessity or an isolated cosmetic challenge? Mini-survey and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Review
  2. Article
  3. Computed Tomography ofVeterinary medicine international · 2026
    Article
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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiawei LiuDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. jiawei.liu@cuanschutz.edu.ORCID http://orcid.org/0000-0001-9523-0252
Jasmine ChaijDepartment of Pediatric Plastic & Reconstructive Surgery, Children's Hospital Colorado, Aurora, CO, USA.
Marius George LinguraruSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
Brooke FrenchDepartment of Pediatric Plastic & Reconstructive Surgery, Children's Hospital Colorado, Aurora, CO, USA.
Robert KeatingDepartment of Neurosurgery, Children's National Hospital, Washington, DC, USA.
Allyson L AlexanderDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, USA.
Antonio R PorrasDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. antonio.porras@cuanschutz.edu.

Funding

Quantitative characterization and predictive modeling of cranial bone development in patients with craniosynostosisR00DE027993 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI PORRAS PEREZ, ANTONIO REYES · 2020 to 2022
$738k
Development of CT image-based cranial bone markers of intra-cranial hypertensionR21DE031824 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI PORRAS PEREZ, ANTONIO REYES · 2023 to 2024
$449k
Colorado Clinical and Translational Sciences Institute UM1 TR004933NIDCR NIH HHS R00 DE027993NIDCR NIH HHS R00DE027993NIDCR NIH HHS R21 DE031824NIDCR NIH HHS R21DE031824
6 · The paper itself

Abstract

purposeThe diagnosis of chronic increased intracranial pressure (IIP)is often based on subjective evaluation or clinical metrics with low predictive value. We aimed to quantify cranial bone changes associated with pediatric IIP using CT images and to identify patients at risk.

methodsWe retrospectively quantified local cranial bone thickness and mineral density from the CT images of children with chronic IIP and compared their statistical differences to normative children without IIP adjusting for age, sex and image resolution. Subsequently, we developed a classifier to identify IIP based on these measurements. Finally, we demonstrated our methods to explore signs of IIP in patients with non-syndromic sagittal craniosynostosis (NSSC).

resultsWe quantified a significant decrease of bone density in 48 patients with IIP compared to 1,018 normative subjects (P < .001), but no differences in bone thickness (P = .56 and P = .89 for age groups 0-2 and 2-10 years, respectively). Our classifier demonstrated 83.33% (95% CI: 69.24%, 92.03%) sensitivity and 87.13% (95% CI: 84.88%, 89.10%) specificity in identifying patients with IIP. Compared to normative subjects, 242 patients with NSSC presented significantly lower cranial bone density (P < .001), but no differences were found compared to patients with IIP (P = .57). Of patients with NSSC, 36.78% (95% CI: 30.76%, 43.22%) presented signs of IIP.

conclusionCranial bone changes associated with pediatric IIP can be quantified from CT images to support earlier diagnoses of IIP, and to study the presence of IIP secondary to cranial pathology such as non-syndromic sagittal craniosynostosis.

Indexed as

Bone DensityIntracranial HypertensionSkullTomography, X-Ray ComputedChildChild, PreschoolChronic DiseaseCraniosynostosesFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesSensitivity and SpecificityCranial bone anomaliesHead CT imagePediatric chronic increased intracranial pressure

Identifiers

PMID38871879
PMCPMC11424726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.