Evidence map›Paper›PMID 38871831›Full record

ArticleScientific reports2024

Ingestion of amoxicillin-clavulanic acid at therapeutic concentration during blood meal impacts Aedes aegypti microbiota and dengue virus transmission.

Margot Garcia-Van Smévoorde, Elodie Calvez, Isaure Quétel, Christelle Dollin, Sébastien Breurec, Anubis Vega-Rúa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Microbial gatekeepers: midgut bacteria inFrontiers in microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margot Garcia-Van SmévoordeVector Control Research Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de La Guadeloupe, 97139, Les Abymes, Guadeloupe, France.
Elodie CalvezVector Control Research Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de La Guadeloupe, 97139, Les Abymes, Guadeloupe, France.
Isaure QuételMicrobial Ecosystems Interaction Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de La Guadeloupe, 97139, Les Abymes, Guadeloupe, France.
Christelle DollinVector Control Research Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de La Guadeloupe, 97139, Les Abymes, Guadeloupe, France.
Sébastien BreurecMicrobial Ecosystems Interaction Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de La Guadeloupe, 97139, Les Abymes, Guadeloupe, France.
Anubis Vega-RúaVector Control Research Laboratory, Transmission Reservoir and Pathogens Diversity Unit, Institut Pasteur de La Guadeloupe, 97139, Les Abymes, Guadeloupe, France. avegarua@pasteur-guadeloupe.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV), mainly transmitted by Aedes aegypti mosquitoes, is the most prevalent arbovirus worldwide, representing a public health problem in tropical and subtropical countries. In these areas, antibiotic consumption rises which may impact both mosquito microbiota and dengue transmission. Here, we assessed how the ingestion by Ae. aegypti of therapeutic concentrations of amoxicillin-clavulanic Acid association (Amox/Clav), a broad-spectrum antibiotic used to treat febrile symptoms worldwide, impacted its microbiota. We also evaluated whether simultaneous ingestion of antibiotic and DENV impacted Ae. aegypti ability to transmit this virus. We found that Amox/Clav ingestion impacted microbiota composition in Ae. aegypti and we confirmed such impact in field-collected mosquitoes. Furthermore, we observed that Amox/Clav ingestion enhanced DENV dissemination and transmission by this mosquito at 21 days post-DENV exposure. These findings increase our understanding of factors linked to human hosts that may influence dengue transmission dynamics in regions with mass-drug administration programs.

Indexed as

AedesDengueDengue VirusMicrobiotaAmoxicillin-Potassium Clavulanate CombinationAnimalsAnti-Bacterial AgentsFemaleHumansMosquito VectorsAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial Agents

Identifiers

PMID38871831
PMCPMC11176339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.