ArticleNature communications2024
Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits.Molecular psychiatry · 2026Article
- Socioeconomic Position and Somatic Comorbidity in Mental Disorders.Acta psychiatrica Scandinavica · 2026Article
- Shared Genetic Architecture of Premenstrual Disorder and Postpartum Depression: Registry-Based and Genetic Evidence.Research square · 2026Article
- Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease.Communications medicine · 2026Article
- Association of Genetic Liability to Psychiatric Disorders with Peripheral Metabolic Dysregulation.medRxiv : the preprint server for health sciences · 2026Article
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions.Molecular psychiatry · 2026Article
- Familial coaggregation and shared genetic loading of mental disorders and cardiovascular diseases.Psychological medicine · 2026Article
- Impact of a single fecal microbiome transplantation in adult women with anorexia nervosa: an open-label feasibility pilot trial.Nature communications · 2026Article
- Population-Level Co-Distribution and Spatiotemporal Burden Trends of Endometriosis and Polycystic Ovary Syndrome Among Reproductive-Age Women in Europe, 1990-2023: An Analysis of the Global Burden of Disease 2023.International journal of women's health · 2026Article
- Spousal correlations for nine psychiatric disorders are consistent across cultures and persistent over generations.Nature human behaviour · 2025Article
- Associations of Genetic Liability to Six Psychiatric Disorders With Cardiometabolic Diseases.medRxiv : the preprint server for health sciences · 2025Article
- Bipolar disorder.Lancet (London, England) · 2025Review
- Familial co-aggregation and shared heritability between clinically diagnosed neurodevelopmental problems and cardiometabolic conditions: a nationwide register study across three generations.Research square · 2025Article
- Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study.BMC medicine · 2025Article
- Shared genetic architecture between eating disorders, mental health conditions, and cardiometabolic diseases: a comprehensive population-wide study across two countries.Nature communications · 2025Article
- Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK.The lancet. Psychiatry · 2025Observational
- Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis.BMC pregnancy and childbirth · 2025Article
- Association of single nucleotide polymorphisms and gene-environment interactions with major depressive disorder in Chinese.Heliyon · 2024Article
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23 authors.
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Abstract
Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.
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