Evidence map›Paper›PMID 38871751›Full record

ArticleScientific reports2024

Combating the causative agent of amoebic keratitis, Acanthamoeba castellanii, using Padina pavonica alcoholic extract: toxicokinetic and molecular docking approaches.

Sara S Abdel-Hakeem, Faten A M Hassan, Awatief F Hifney, Shimaa H Salem

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Silver(I)-NHC Complexes as Dual-Action Agents Against PathogenicInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sara S Abdel-HakeemParasitology Laboratory, Zoology and Entomology Department, Faculty of Science, Assiut University, Assiut, 71526, Egypt.ORCID 0000-0003-1069-5806
Faten A M HassanMicrobiology Department, Faculty of Science, Taiz University, Taiz, Yemen.
Awatief F HifneyBotany and Microbiology Department, Faculty of Science, Assiut University, Assiut, 71526, Egypt.
Shimaa H SalemBotany and Microbiology Department, Faculty of Science, Assiut University, Assiut, 71526, Egypt. shimaa.hassan@aun.edu.eg.ORCID 0000-0002-2965-8143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products play a significant role in providing the current demand as antiparasitic agents, which offer an attractive approach for the discovery of novel drugs. The present study aimed to evaluate in vitro the potential impact of seaweed Padina pavonica (P. pavonica) extract in combating Acanthamoeba castellanii (A. castellanii). The phytochemical constituents of the extract were characterized by Gas chromatography-mass spectrometry. Six concentrations of the algal extract were used to evaluate its antiprotozoal activity at various incubation periods. Our results showed that the extract has significant inhibition against trophozoites and cysts viability, with complete inhibition at the high concentrations. The IC

Indexed as

Acanthamoeba castellaniiAcanthamoeba KeratitisMolecular Docking SimulationPlant ExtractsAnimalsAntiprotozoal AgentsHumansTrophozoitesAntiprotozoal AgentsPlant ExtractsAcanthamoeba castellaniiADME analysisAmoebic keratitisCytochrome P450 monooxygenaseMolecular docking

Identifiers

PMID38871751
PMCPMC11176165

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.