Evidence map›Paper›PMID 38871720›Full record

ArticleNature communications2024

E proteins control the development of NKγδT cells through their invariant T cell receptor.

Ariana Mihai, Sang-Yun Lee, Susan Shinton, Mitchell I Parker, Alejandra V Contreras, Baojun Zhang, Michele Rhodes, Roland L Dunbrack, Juan-Carlos Zúñiga-Pflücker, Maria Ciofani and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. γδ T cells and cancer.The Journal of clinical investigation · 2026
    Review
  2. T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ariana Mihai *Immunology Department, Duke University, Durham, NC, USA.ORCID 0000-0002-6563-400X
Sang-Yun Lee *Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Susan ShintonNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0003-2649-1904
Mitchell I ParkerCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Alejandra V ContrerasNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Baojun ZhangImmunology Department, Duke University, Durham, NC, USA.ORCID 0000-0002-7786-4304
Michele RhodesNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0009-0009-3194-3304
Roland L DunbrackCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0001-7674-6667
Juan-Carlos Zúñiga-PflückerImmunology Department, University of Toronto, Toronto, CA, USA.ORCID 0000-0003-2538-3178
Maria CiofaniImmunology Department, Duke University, Durham, NC, USA.ORCID 0000-0001-6472-5260
Yuan ZhuangImmunology Department, Duke University, Durham, NC, USA.
David L WiestNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA. David.Wiest@fccc.edu.ORCID 0000-0002-0792-3188

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI Maria Ciofani · 2014 to 2026
$26.3M
HEB MEDIATED PATHWAYS AND FUNCTION IN T CELL DEVELOPMENTR01GM059638 · NIGMS · DUKE UNIVERSITY · PI CHAN, FRANCIS KAMING · 1999 to 2021
$6.9M
Structural Bioinformatics of Proteins and Protein Complexes and Applications to Cancer BiologyR35GM122517 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI ROLAND L DUNBRACK · 2017 to 2026
$6.3M
The role of AP-1 family transcription factor networks in regulating TH17 cell effector identityR01GM115474 · NIGMS · DUKE UNIVERSITY · PI CIOFANI, MARIA · 2016 to 2024
$3.2M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) P01AI102853NCI NIH HHS P30 CA006927NIAID NIH HHS P01 AI102853NIGMS NIH HHS R01 GM059638NIGMS NIH HHS R01 GM115474NIGMS NIH HHS R35 GM122517
6 · The paper itself

Abstract

T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces different phenotypes in distinct γδ T cell subsets. Here, we show that Id3 deficiency impairs development of the Vγ3

Indexed as

Inhibitor of Differentiation ProteinsReceptors, Antigen, T-Cell, gamma-deltaAnimalsCell DifferentiationMiceMice, Inbred C57BLMice, KnockoutSignal TransductionT-Lymphocyte SubsetsIdb3 protein, mouseInhibitor of Differentiation ProteinsReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID38871720
PMCPMC11176164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.