ArticleNature communications2024
Potential pandemic risk of circulating swine H1N2 influenza viruses.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanistic Models of Influenza Transmission in Commercial Swine Populations: A Systematic Review.Pathogens (Basel, Switzerland) · 2024Pooled it
- A lethal human H5N5 influenza virus isolate exhibits low pandemic risk traits.bioRxiv : the preprint server for biology · 2026Article
- Fatal human H3N8 influenza virus has a moderate pandemic risk.PLoS pathogens · 2026Article
- Paired versus Single Housing of Ferrets (Mustela putorius furo) Does Not Influence Experimental Outcomes of Influenza A Virus Pathogenesis Studies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Eurasian 1C swine influenza A virus exhibits high pandemic risk traits.Emerging microbes & infections · 2025Article
- Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk.bioRxiv : the preprint server for biology · 2025Article
- Development of Dual 'RT-LAMP-LFA' Rapid Detection Technology With Gold Magnetic Nanoparticles for Influenza Virus.Microbial biotechnology · 2025Article
- Article
- Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model.Emerging infectious diseases · 2025Article
- Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity.Emerging infectious diseases · 2025Article
- Estimating the risk of zoonotic transmission of swine influenza A variant during agricultural fairs in the United States: a mathematical modeling.Frontiers in veterinary science · 2025Article
- Evaluating preventive measures for the zoonotic transmission of swine influenza A variant at agricultural fairs in the United States: a mathematical modeling study.Frontiers in veterinary science · 2025Article
- Progress and persistence of diseases of high consequence to livestock in the United States.One health (Amsterdam, Netherlands) · 2024Review
- Pre-existing H1N1 immunity reduces severe disease with bovine H5N1 influenza virus.bioRxiv : the preprint server for biology · 2024Article
- Bovine H5N1 influenza virus binds poorly to human-type sialic acid receptors.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
Abstract
Influenza A viruses in swine have considerable genetic diversity and continue to pose a pandemic threat to humans due to a potential lack of population level immunity. Here we describe a pipeline to characterize and triage influenza viruses for their pandemic risk and examine the pandemic potential of two widespread swine origin viruses. Our analysis reveals that a panel of human sera collected from healthy adults in 2020 has no cross-reactive neutralizing antibodies against a α-H1 clade strain (α-swH1N2) but do against a γ-H1 clade strain. The α-swH1N2 virus replicates efficiently in human airway cultures and exhibits phenotypic signatures similar to the human H1N1 pandemic strain from 2009 (H1N1pdm09). Furthermore, α-swH1N2 is capable of efficient airborne transmission to both naïve ferrets and ferrets with prior seasonal influenza immunity. Ferrets with H1N1pdm09 pre-existing immunity show reduced α-swH1N2 viral shedding and less severe disease signs. Despite this, H1N1pdm09-immune ferrets that became infected via the air can still onward transmit α-swH1N2 with an efficiency of 50%. These results indicate that this α-swH1N2 strain has a higher pandemic potential, but a moderate level of impact since there is reduced replication fitness and pathology in animals with prior immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.