Evidence map›Paper›PMID 38871391›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager.

Hongdi Li, Ramsey D Badawi, Simon R Cherry, Kathryn Fontaine, Liuchun He, Shannan Henry, Ansel T Hillmer, Lingzhi Hu, Nikkita Khattar, Edwin K Leung and 19 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07509125 narecruitingnot on this mapstarted 2026, after this paper: background citation

Ultra-High Resolution PET of the Human Brain and Spinal Cord in Healthy Aging, Dementia, Movement Disorders, ALS and Psychotic Disorders

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2026 to 2029Enrolled300ConditionsAlzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis, Parkinson s Disease, REM Sleep Behavior Disorder (iRBD)ArmsUHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1, UHR PET/CT scan of the brain with ¹⁸F-MK6240, 3T MRI imaging of the brain
NCT07595666 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Prospective Comparison of Ultra-high Resolution NeuroExplorer PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region

TypeinterventionalSponsorprof. dr. Koen Van LaereRan2025 to 2030Enrolled1,600ConditionsDementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, EpilepsyArmsStandard-of-care PET/CT, NeuroEXPLORER
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Prospective Multicenter Evaluation of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  3. Article
  4. Human cerebral cortex organization characterized by functional PET-FDG "Metabolic Connectivity".European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Performance Evaluation of SmartBrain: A Wearable PET System for Human Brain Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. "Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  13. Article
  14. High-resolution [European journal of nuclear medicine and molecular imaging · 2026
    Article
  15. Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  16. Article
  17. Article
  18. High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Hongdi LiUnited Imaging Healthcare North America, Houston, Texas.
Ramsey D BadawiUniversity of California, Davis, Davis, California.
Simon R CherryUniversity of California, Davis, Davis, California.
Kathryn FontaineYale University, New Haven, Connecticut; and.
Liuchun HeUnited Imaging Healthcare, Shanghai, China.
Shannan HenryYale University, New Haven, Connecticut; and.
Ansel T HillmerYale University, New Haven, Connecticut; and.
Lingzhi HuUnited Imaging Healthcare North America, Houston, Texas.
Nikkita KhattarYale University, New Haven, Connecticut; and.
Edwin K LeungUnited Imaging Healthcare North America, Houston, Texas.
Tiantian LiUnited Imaging Healthcare North America, Houston, Texas.
Yusheng LiUnited Imaging Healthcare North America, Houston, Texas.
Chi LiuYale University, New Haven, Connecticut; and.
Peng LiuUnited Imaging Healthcare, Shanghai, China.
Zhenrui LuUnited Imaging Healthcare, Shanghai, China.
Stanislaw MajewskiUniversity of California, Davis, Davis, California.
David MatuskeyYale University, New Haven, Connecticut; and.
Evan D MorrisYale University, New Haven, Connecticut; and.
Tim MulnixYale University, New Haven, Connecticut; and.
Negar OmidvariUniversity of California, Davis, Davis, California.
Suranjana SamantaUnited Imaging Healthcare North America, Houston, Texas.
Aaron SelfridgeUnited Imaging Healthcare North America, Houston, Texas.
Xishan SunUnited Imaging Healthcare North America, Houston, Texas.
Takuya ToyonagaYale University, New Haven, Connecticut; and.
Tommaso VolpiYale University, New Haven, Connecticut; and.
Tianyi ZengYale University, New Haven, Connecticut; and.
Terry JonesUniversity of California, Davis, Davis, California.
Jinyi QiUniversity of California, Davis, Davis, California.
Richard E CarsonYale University, New Haven, Connecticut; and richard.carson@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of NeurochemistryU01EB029811 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LI, HONGDI · 2020 to 2024
$10.0M
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS U01 EB029811
6 · The paper itself

Abstract

The collaboration of Yale, the University of California, Davis, and United Imaging Healthcare has successfully developed the NeuroEXPLORER, a dedicated human brain PET imager with high spatial resolution, high sensitivity, and a built-in 3-dimensional camera for markerless continuous motion tracking. It has high depth-of-interaction and time-of-flight resolutions, along with a 52.4-cm transverse field of view (FOV) and an extended axial FOV (49.5 cm) to enhance sensitivity. Here, we present the physical characterization, performance evaluation, and first human images of the NeuroEXPLORER.

Indexed as

BrainPhantoms, ImagingPositron Emission Tomography Computed TomographyFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedFluorodeoxyglucose F18brain PETDOIhigh resolutionNEMANeuroEXPLORER

Identifiers

PMID38871391
PMCPMC11294061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.