Evidence map›Paper›PMID 38871388›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Synthesis of

German O Fonseca Cabrera, Xinrui Ma, Wilson Lin, Tao Zhang, Weiling Zhao, Liqin Pan, Xiaomei Li, Todd E Barnhart, Eduardo Aluicio-Sarduy, Huaifu Deng and 5 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Emerging Theranostic Radiometals (Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Review
  3. [Advances in multimodal biomedical imaging of small animals].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

German O Fonseca CabreraBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Xinrui MaBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Wilson LinDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin; and.
Tao ZhangBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Weiling ZhaoBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Liqin PanBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Xiaomei LiAccunovo Biotechnologies, Inc., Chapel Hill, North Carolina.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin; and.
Eduardo Aluicio-SarduyDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin; and.
Huaifu DengBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Xuedan WuBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Kadalipura P RakeshBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Zibo LiBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; ziboli@med.unc.edu jwengle@wisc.edu zhanhong_wu@med.unc.edu.
Jonathan W EngleJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina; ziboli@med.unc.edu jwengle@wisc.edu zhanhong_wu@med.unc.edu.
Zhanhong WuBiomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; ziboli@med.unc.edu jwengle@wisc.edu zhanhong_wu@med.unc.edu.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Radionuclide Production and Radiochemistry Core Description CoreP01CA250972 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MORRIS, ZACHARY SCOTT, WEICHERT, JAMEY P · 2020 to 2024
$12.5M
The development of novel radiation-sensitizer based on ultra-small carbon dotsR01CA247769 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, XIE, JIN · 2020 to 2024
$2.5M
Small Animal PET/CT for Preclinical Imaging ResearchS10OD023611 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2017 to 2017
$835k
Theranostic NTSR1-targeting Agents for Complementary Management of PSMA-negative Prostate CancerR43CA261503 · NCI · ACCUNOVO BIOTECHNOLOGIES INC · PI LI, XIAOMEI · 2022 to 2022
$376k
NCI NIH HHS P01 CA250972NCI NIH HHS P30 CA014520NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA247769NCI NIH HHS R43 CA261503NIH HHS S10 OD023611
6 · The paper itself

Abstract

The development of theranostic radiotracers relies on their binding to specific molecular markers of a particular disease and the use of corresponding radiopharmaceutical pairs thereafter. This study reports the use of multiamine macrocyclic moieties (MAs), as linkers or chelators, in tracers targeting the neurotensin receptor-1 (NTSR-1). The goal is to achieve elevated tumor uptake, minimal background interference, and prolonged tumor retention in NTSR-1-positive tumors.

Indexed as

Copper RadioisotopesGallium RadioisotopesMacrocyclic CompoundsRadiopharmaceuticalsReceptors, NeurotensinAminesAnimalsCell Line, TumorChemistry Techniques, SyntheticHumansIsotope LabelingMicePositron Emission Tomography Computed TomographyPrecision MedicineRadiochemistryTissue DistributionAminesCopper-64Copper RadioisotopesGallium-68Gallium RadioisotopesMacrocyclic Compoundsneurotensin type 1 receptorRadiopharmaceuticalsReceptors, Neurotensin55Co64Cu68Ganeurotensin receptorPETprostate cancerradiotheranostic agent

Identifiers

PMID38871388
PMCPMC11294072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.