Evidence map›Paper›PMID 38870452›Full record

Observational studyNeurology2024

Incidence and Types of Cardiac Arrhythmias in the Peri-Ictal Period in Patients Having a Generalized Convulsive Seizure.

Laura Vilella, Christina Y Miyake, Ganne Chaitanya, Johnson P Hampson, Shirin Jamal Omidi, Manuela Ochoa-Urrea, Blanca Talavera, Oscar Mancera, Norma J Hupp, Jaison S Hampson and 17 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  5. Observational
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Laura VilellaFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0003-2621-4413
Christina Y MiyakeFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Ganne ChaitanyaFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0002-1578-4210
Johnson P HampsonFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Shirin Jamal OmidiFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Manuela Ochoa-UrreaFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0003-4157-701X
Blanca TalaveraFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Oscar ManceraFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Norma J HuppFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0001-7850-141X
Jaison S HampsonFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
M R Sandhya RaniFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Nuria LacueyFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0002-6067-7414
Shiqiang TaoFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Rup K SainjuFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0002-8414-1972
Daniel FriedmanFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0003-1068-1797
Maromi NeiFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0001-7197-3094
Catherine A ScottFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0002-5363-6665
Brian GehlbachFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0003-3160-1741
Stephan U SchueleFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0003-3261-7120
Jennifer A OgrenFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Ronald M HarperFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Beate DiehlFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0002-6896-854X
Lisa M BatemanFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Orrin DevinskyFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0003-0044-4632
George B RichersonFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0001-5696-1554
Guo-Qiang ZhangFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.
Samden D LhatooFrom the Departament de Medicina (L.V.), Universitat Autònoma de Barcelona, Spain; NINDS Center for SUDEP Research (CSR) (L.V., G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., R.K.S., D.F., M.N., C.A.S., B.G., S.U.S., R.M.H., B.D., L.M.B., O.D., G.B.R., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Neurology (L.V.), Hospital del Mar, Barcelona, Spain; Division of Cardiology (C.Y.M.), Department of Pediatrics, Texas Children's Hospital, and Department of Molecular Physiology and Biophysics (C.Y.M.), Baylor College of Medicine, Houston, TX; Department of Neurology (G.C., J.P.H., S.J.O., M.O.-U., B.T., O.M., N.J.H., J.S.H., M.R.S.R., N.L., S.T., G.-Q.Z., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; University of Iowa Carver College of Medicine (R.K.S., B.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.A.S., B.D.), University College London, United Kingdom; Department of Neurology (S.U.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurobiology and the Brain Research Institute (R.M.H.), and Department of Neurobiology (J.A.O.), University of California, Los Angeles; and Cedars-Sinai Medical Center (L.M.B.), Los Angeles, CA.ORCID 0000-0002-0260-3855

Funding

SUDEP Translational Research Alliance (SUTRA): Autonomic and Imaging Biomarkers of SUDEP; SUTRA 3 of 7U01NS090407 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DIEHL, BEATE, HARPER, RONALD MARVEN · 2014 to 2018
$7.3M
The role of central CO2 chemosensitivity in postictal respiratory depression and SUDEPR01NS113764 · NINDS · UNIVERSITY OF IOWA · PI Brian Gehlbach, GEORGE B RICHERSON · 2019 to 2026
$5.5M
SUDEP Research Alliance: Respiratory and Arousal Mechanisms, Application 5 of 7U01NS090414 · NINDS · UNIVERSITY OF IOWA · PI RICHERSON, GEORGE B · 2014 to 2018
$3.3M
The Administrative Core of the Center of SUDEP ResearchU01NS090405 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LHATOO, SAMDEN, NOEBELS, JEFFREY · 2014 to 2018
$3.2M
NINDS NIH HHS R01 NS113764NINDS NIH HHS U01 NS090405NINDS NIH HHS U01 NS090407NINDS NIH HHS U01 NS090414
6 · The paper itself

Abstract

BACKGROUND AND

objectivesGeneralized convulsive seizures (GCSs) are the main risk factor of sudden unexpected death in epilepsy (SUDEP), which is likely due to peri-ictal cardiorespiratory dysfunction. The incidence of GCS-induced cardiac arrhythmias, their relationship to seizure severity markers, and their role in SUDEP physiopathology are unknown. The aim of this study was to analyze the incidence of seizure-induced cardiac arrhythmias, their association with electroclinical features and seizure severity biomarkers, as well as their specific occurrences in SUDEP cases.

methodsThis is an observational, prospective, multicenter study of patients with epilepsy aged 18 years and older with recorded GCS during inpatient video-EEG monitoring for epilepsy evaluation. Exclusion criteria were status epilepticus and an obscured video recording. We analyzed semiologic and cardiorespiratory features through video-EEG (VEEG), electrocardiogram, thoracoabdominal bands, and pulse oximetry. We investigated the presence of bradycardia, asystole, supraventricular tachyarrhythmias (SVTs), premature atrial beats, premature ventricular beats, nonsustained ventricular tachycardia (NSVT), atrial fibrillation (Afib), ventricular fibrillation (VF), atrioventricular block (AVB), exaggerated sinus arrhythmia (ESA), and exaggerated sinus arrhythmia with bradycardia (ESAWB). A board-certified cardiac electrophysiologist diagnosed and classified the arrhythmia types. Bradycardia, asystole, SVT, NSVT, Afib, VF, AVB, and ESAWB were classified as arrhythmias of interest because these were of SUDEP pathophysiology value. The main outcome was the occurrence of seizure-induced arrhythmias of interest during inpatient VEEG monitoring. Moreover, yearly follow-up was conducted to identify SUDEP cases. Binary logistic generalized estimating equations were used to determine clinical-demographic and peri-ictal variables that were predictive of the presence of seizure-induced arrhythmias of interest. The

resultsThis study includes data from 249 patients (mean age 37.2 ± 23.5 years, 55% female) who had 455 seizures. The most common arrhythmia was ESA, with an incidence of 137 of 382 seizures (35.9%) (106/224 patients [47.3%]). There were 50 of 352 seizure-induced arrhythmias of interest (14.2%) in 41 of 204 patients (20.1%). ESAWB was the commonest in 22 of 394 seizures (5.6%) (18/225 patients [8%]), followed by SVT in 18 of 397 seizures (4.5%) (17/228 patients [7.5%]). During follow-up (48.36 ± 31.34 months), 8 SUDEPs occurred. Seizure-induced bradycardia (3.8% vs 12.5%, DISCUSSION: Markers of seizure severity are not related to seizure-induced arrhythmias of interest, suggesting that other factors such as occult cardiac abnormalities may be relevant for their occurrence. Seizure-induced ESAWB and bradycardia were more frequent in SUDEP cases, although this observation was based on a very limited number of SUDEP patients. Further case-control studies are needed to evaluate the yield of arrhythmias of interest along with respiratory changes as potential SUDEP biomarkers.

Indexed as

Arrhythmias, CardiacElectroencephalographyAdolescentAdultAgedElectrocardiographyEpilepsy, GeneralizedFemaleHumansIncidenceMaleMiddle AgedProspective StudiesSeizuresSudden Unexpected Death in EpilepsyYoung Adult

Identifiers

PMID38870452
PMCPMC11759939

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