Evidence map›Paper›PMID 38870350›Full record

SynthesisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Efficacy and Safety of Rivaroxaban Versus Enoxaparin in Prevention of Recurrence of Venous Thrombo-Embolism Events in Cancer Patients: A Meta-Analysis.

Abdul Rafeh Awan, Abdullah Ahmad, Muhammad Daniyal, Malik Muhammad Hamza Khan, Shaikh Jehanzaib Saeed, Muhammad Bilal Siddiqui, Sheraz Hakeem, Azka Shahab, Syed Hasham Ali, Ahmed Kamal Siddiqi

Abstract readMeta-AnalysisComparative StudyReview
In one paragraph

Synthesis in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdul Rafeh AwanDepartment of Medicine, Nishtar Medical University, Multan, Pakistan.ORCID 0000-0002-6411-8759
Abdullah AhmadCombined Military Hospital (CMH) Medical College, Lahore, Punjab.
Muhammad DaniyalCombined Military Hospital (CMH) Medical College, Lahore, Punjab.
Malik Muhammad Hamza KhanDepartment of Medicine, Aga Khan University, Karachi, Pakistan.
Shaikh Jehanzaib SaeedDepartment of Medicine, Aga Khan University, Karachi, Pakistan.
Muhammad Bilal SiddiquiDepartment of Medicine, Aga Khan University, Karachi, Pakistan.
Sheraz HakeemDepartment of Medicine, Aga Khan University, Karachi, Pakistan.
Azka ShahabDepartment of Medicine, Bahria University Medical and Dental College, Karachi, Pakistan.
Syed Hasham AliDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Ahmed Kamal SiddiqiDivision of Cardiothoracic Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the effectiveness of rivaroxaban compared to enoxaparin in patients diagnosed with cancer and venous thromboembolism.

methodsA search of Pub Med, Scopus, and Google Scholar, from inception through April 2023 was conducted. Articles comparing rivaroxaban with enoxaparin in patients with cancer and VTE/PE/DVT were included. Review Manager Version 5.2 was utilised for the analysis of the following outcomes; VTE, PE, DVT, major bleeding, and mortality.

resultsA total of 8 articles and 2276 patients were included in the final analysis. Pooled analysis showed that rivaroxaban had a statistically insignificant reduced association with VTE occurrence (RR:0.83, 95% CI:0.58-1.18, P:0.3) as well as a statically insignificant reduction in major bleeding (RR:0.79, 95% CI:0.53-1.18, P:0.25). Analysis showcased that there was an insignificant reduction of mortality rivaroxaban as compared to enoxaparin (RR:0.74, 95% CI: 0.46-1.20, P:0.23).

conclusionRivaroxaban can serve as a viable alternative to enoxaparin, with no appreciable drawbacks, for preventing and managing VTE in patients with malignancy.

Indexed as

EnoxaparinNeoplasmsRivaroxabanVenous ThromboembolismAnticoagulantsHemorrhageHumansRecurrenceAnticoagulantsEnoxaparinRivaroxabancancerchemotherapyenoxaparinlow molecular weight heparinrivaroxabanvenous thromboembolism

Identifiers

PMID38870350
PMCPMC11179539

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.