ArticleScience (New York, N.Y.)2024
Integrated platform for multiscale molecular imaging and phenotyping of the human brain.
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Accelerated immunostaining of thick biological tissues using bidirectional electric fields with reversible deformation.Biomedical optics express · 2026Article
- Multiscale Design Principles for Nanocomposite Hydrogel-Based Triboelectric Nanogenerators.Nano letters · 2026Article
- Genetically Encoded Melanin as a Photostable Scattering Contrast for Whole-Brain Tomography.bioRxiv : the preprint server for biology · 2026Article
- SynClear: A one-step synchronous clearing and labeling strategy for multiscale 3D brain mapping.Materials today. Bio · 2026Article
- Reconfigurable Nanogap SERS for Multiscale Molecular Sensing on Curved Surfaces.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.Reviews in endocrine & metabolic disorders · 2026Review
- Heterogeneity of White Matter Structure in the Human Brain.Research square · 2026Article
- VesSynth: Tubes Are All You Need for Robust Cross-Scale Cross-Modal 3D Vessel Segmentation.bioRxiv : the preprint server for biology · 2026Article
- Heterogeneity of white-matter organization in the human brain.bioRxiv : the preprint server for biology · 2026Article
- CellPheno: A High-throughput Computational Platform for Quantifying Cellular Resolution Whole Brain Microscopy Images.bioRxiv : the preprint server for biology · 2026Article
- Article
- Computation and resource efficient genome-wide association analysis for large-scale imaging studies.Nature communications · 2026Article
- Article
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Multi-organ AI endophenotypes chart the heterogeneity of brain, eye and heart pan-disease.Nature. Mental health · 2026Article
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Multiscale measurement of brain tissue and cell biomechanics using a mouse model.Biophysics reports · 2025Article
- Whole-brain reconstruction of fiber tracts based on cytoarchitectonic organization.Nature methods · 2025Article
- Dendritome mapping reveals the spatial organization of striatal neuron morphology.Nature neuroscience · 2025Article
- Uniform volumetric single-cell processing for organ-scale molecular phenotyping.Nature biotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Funding
Abstract
Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of individual cells and their connectivity in the human organ-scale system. We developed a platform that simultaneously extracts spatial, molecular, morphological, and connectivity information of individual cells from the same human brain. The platform includes three core elements: a vibrating microtome for ultraprecision slicing of large-scale tissues without losing cellular connectivity (MEGAtome), a polymer hydrogel-based tissue processing technology for multiplexed multiscale imaging of human organ-scale tissues (mELAST), and a computational pipeline for reconstructing three-dimensional connectivity across multiple brain slabs (UNSLICE). We applied this platform for analyzing human Alzheimer's disease pathology at multiple scales and demonstrating scalable neural connectivity mapping in the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.