Evidence map›Paper›PMID 38870275›Full record

ArticleScience (New York, N.Y.)2024

Structural basis of odor sensing by insect heteromeric odorant receptors.

Jiawei Zhao, Andy Q Chen, Jaewook Ryu, Josefina Del Mármol

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Scent and adhesion drive insect dispersal of environmental yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Article
  18. Review
  19. Semiochemicals and odorant receptors underlying potato cultivar susceptibility and resistance to potato tuber moth.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiawei ZhaoDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0582-2105
Andy Q ChenDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4970-045X
Jaewook RyuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0002-6486-5022
Josefina Del MármolDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2715-0482

Funding

Elucidating the structural determinants of odor specificity in insect olfactory receptorsR00DC019401 · NIDCD · HARVARD MEDICAL SCHOOL · PI DEL MARMOL, JOSEFINA INÉS · 2022 to 2024
$747k
Howard Hughes Medical InstituteNIDCD NIH HHS R00 DC019401
6 · The paper itself

Abstract

Most insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo-electron microscopy structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos

Indexed as

AedesAnophelesCryoelectron MicroscopyInsect ProteinsOdorantsReceptors, OdorantAnimalsProtein MultimerizationProtein SubunitsInsect ProteinsProtein SubunitsReceptors, Odorant

Identifiers

PMID38870275
PMCPMC11235583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.