Evidence map›Paper›PMID 38870015›Full record

ArticleCell reports2024

Causal evidence for cholinergic stabilization of attractor landscape dynamics.

Natasha L Taylor, Christopher J Whyte, Brandon R Munn, Catie Chang, Joseph T Lizier, David A Leopold, Janita N Turchi, Laszlo Zaborszky, Eli J Műller, James M Shine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natasha L TaylorBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia.
Christopher J WhyteBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia.
Brandon R MunnBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia.
Catie ChangVanderbilt School of Engineering, Vanderbilt University, Nashville, TN, USA.
Joseph T LizierCentre for Complex Systems, The University of Sydney, Sydney, NSW, Australia; School of Computer Science, The University of Sydney, Sydney, NSW, Australia.
David A LeopoldNeurophysiology Imaging Facility, National Institute of Mental Health, Washington DC, USA; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda MD, USA.
Janita N TurchiLaboratory of Neuropsychology, National Institute of Mental Health, Bethesda MD, USA.
Laszlo ZaborszkyCentre for Molecular & Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Eli J MűllerBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia.
James M ShineBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia. Electronic address: mac.shine@sydney.edu.au.

Funding

Neurophysiology Imaging Facility Core: Functional and Structural MRIZICMH002899 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEOPOLD, DAVID A · 2009 to 2025
$29.1M
The Neural Underpinnings of Functional MRI NetworksZIAMH002896 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEOPOLD, DAVID A · 2009 to 2025
$13.6M
Intramural NIH HHS ZIC MH002899
6 · The paper itself

Abstract

There is substantial evidence that neuromodulatory systems critically influence brain state dynamics; however, most work has been purely descriptive. Here, we quantify, using data combining local inactivation of the basal forebrain with simultaneous measurement of resting-state fMRI activity in the macaque, the causal role of long-range cholinergic input to the stabilization of brain states in the cerebral cortex. Local inactivation of the nucleus basalis of Meynert (nbM) leads to a decrease in the energy barriers required for an fMRI state transition in cortical ongoing activity. Moreover, the inactivation of particular nbM sub-regions predominantly affects information transfer in cortical regions known to receive direct anatomical projections. We demonstrate these results in a simple neurodynamical model of cholinergic impact on neuronal firing rates and slow hyperpolarizing adaptation currents. We conclude that the cholinergic system plays a critical role in stabilizing macroscale brain state dynamics.

Indexed as

Magnetic Resonance ImagingAcetylcholineAnimalsBasal Nucleus of MeynertCerebral CortexCholinergic NeuronsMacaca mulattaMaleModels, NeurologicalNeuronsAcetylcholineacetylcholineattractor landscapebrain statescholinergicCP: NeurosciencedynamicsfMRIneural mass modelneuromodulation

Identifiers

PMID38870015
PMCPMC11255396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.