Evidence map›Paper›PMID 38869819›Full record

ArticleImmunologic research2024

DNA demethylase Tet2 promotes the terminal maturation of natural killer cells.

Yuqing Lin, Biyun Yang, Hailin Liu, Guanghe Ran, Liang Song, Meng Meng, Xiaofeng Yin, Qinghua Bi, Dongmei Yan, Youcai Deng and 1 more

Abstract read
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In one paragraph

Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuqing LinDepartment of Immunology, School of Basic Medical, Jiamusi University, Jiamusi, 154007, China.
Biyun YangDepartment of Immunology, School of Basic Medical, Jiamusi University, Jiamusi, 154007, China.
Hailin LiuDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China.
Guanghe RanDepartment of Immunology, School of Basic Medical, Jiamusi University, Jiamusi, 154007, China.
Liang SongDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China.
Meng MengDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China.
Xiaofeng YinDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China.
Qinghua BiDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China. qinghua.bi@tmmu.edu.cn.
Dongmei YanDepartment of Immunology, School of Basic Medical, Jiamusi University, Jiamusi, 154007, China. yandongmei@jmsu.edu.cn.
Youcai DengDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China. youcai.deng@tmmu.edu.cn.ORCID 0000-0001-5488-8576
Yonghui LuDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China. everlightlu@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cytotoxicity feature to eliminate malignant cells makes natural killer (NK) cells a candidate for tumor immunotherapy. However, this scenario is currently hampered by inadequate understanding of the regulatory mechanisms of NK cell development. Ten-Eleven-Translocation 2 (Tet2) is a demethylase whose mutation was recently shown to cause phenotypic defects in NK cells. However, the role of Tet2 in the development and maturation of NK cells is not entirely clear. Here we studied the modulatory role of Tet2 in NK cell development and maturation by generating hematopoietic Tet2 knockout mice and mice with Tet2 conditional deletion in NKp46

Indexed as

Cell DifferentiationDioxygenasesDNA-Binding ProteinsKiller Cells, NaturalMice, KnockoutNatural Cytotoxicity Triggering Receptor 1Proto-Oncogene ProteinsAnimalsAntigens, LyLectins, C-TypeMiceMice, Inbred C57BLPerforinReceptors, ImmunologicAntigens, LyDioxygenasesDNA-Binding ProteinsKlrg1 protein, mouseLectins, C-TypeNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mousePerforinProto-Oncogene ProteinsReceptors, ImmunologicTet2 protein, mouseEomesNatural killer cellNK cell developmentT-betTet2

Identifiers

PMID38869819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.