Evidence map›Paper›PMID 38869811›Full record

SynthesisCurrent cardiology reports2024

The Effectiveness and Safety of Leadless Pacemakers: An Updated Meta-Analysis.

Vinícius Martins Rodrigues Oliveira, André Rivera, Izadora Caiado Oliveira, André Maroccolo de Sousa, Maria Elisa Passos Nishikubo, Frans Serpa, Antônio da Silva Menezes Junior

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current cardiology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vinícius Martins Rodrigues OliveiraDepartment of Medicine, Federal University of Goiás, Goiânia, Brazil.
André RiveraDepartment of Medicine, Nove de Julho University, São Bernardo Do Campo, Brazil.
Izadora Caiado OliveiraDepartment of Medicine, Federal University of Goiás, Goiânia, Brazil.
André Maroccolo de SousaDepartment of Medicine, Federal University of Goiás, Goiânia, Brazil.
Maria Elisa Passos NishikuboDepartment of Medicine, Federal University of Goiás, Goiânia, Brazil.
Frans SerpaDivision of Cardiology, Beth Israel Deaconess Center, Harvard Medical School, Boston, USA.
Antônio da Silva Menezes JuniorDepartment of Medicine, Federal University of Goiás, Goiânia, Brazil. a.menezes.junior@uol.com.br.ORCID http://orcid.org/0000-0003-1751-5206

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeadless pacemakers (LPs) are promising alternatives to traditional transvenous pacemakers (TVPs), but their comparative effectiveness and safety in clinical outcomes remain uncertain.

methodsWe systematically searched PubMed, Embase, Scopus, Cochrane, and ClinicalTrials.gov for studies comparing LPs and TVPs. A restricted maximum likelihood random-effects model was used for all outcomes. Heterogeneity was assessed using I

resultsWe included 21 studies involving 47,229 patients, of whom 12,199 (25.8%) underwent LP implantation. Compared with TVPs, LPs were associated with a significantly lower risk of overall complications (OR 0.61; 95% CI 0.45-0.81; p < 0.01), dislodgement (OR 0.34; 95% CI 0.20-0.56; p < 0.01), and pneumothorax (OR 0.27; 95% CI 0.16-0.46; p < 0.01). No significant difference in all-cause mortality was observed in the overall analysis (OR 1.43; 95% CI 0.65-3.15; p = 0.35) and in studies with multivariate-adjusted data (OR 1.34; 95% CI 0.65-2.78; p = 0.43). However, LPs were associated with a higher risk of pericardial effusion (OR 2.47; 95% CI 1.39-4.38; p < 0.01) and cardiac tamponade (OR 3.75; 95% CI 2.41-5.83; p < 0.01). LPs also demonstrated a lower pacing capture threshold (MD -0.19 V; 95% CI [-0.23 V]-[-0.16 V]; p < 0.01), but no significant difference in impedance (MD 32.63 ohms; 95% CI [-22.50 ohms]-[87.76 ohms]; p = 0.25).

conclusionsThese findings suggest that LPs were associated with lower overall complication rates and similar effectiveness to TVPs. However, randomized controlled trials are warranted to validate these results.

Indexed as

Pacemaker, ArtificialArrhythmias, CardiacCardiac Pacing, ArtificialEquipment DesignHumansPostoperative ComplicationsTreatment OutcomeEfficacyLeadless PacemakerSafetyTransvenous Pacemaker

Identifiers

PMID38869811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.