Evidence map›Paper›PMID 38869752›Full record

ArticleJournal of molecular histology2024

SPP-5 affects larval arrest via insulin signaling pathway in Caenorhabditis elegans.

Guangjie Xie, Zhiyong Shao

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Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Guangjie XieState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Neurosurgery, Fudan University, Shanghai, China.
Zhiyong ShaoState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Neurosurgery, Fudan University, Shanghai, China. shaozy@fudan.edu.cn.

Funding

Ministry of Science and Technology of the People's Republic of China 2021YFA0909300National Natural Science Foundation of China 32170828the Foundation of Shanghai Municipal Education Commission, China 2019-01-07-00-07-E00062the Shanghai Municipal Science and Technology Major Project, China 2018SHZDZX01
6 · The paper itself

Abstract

Diapause is an endocrine-mediated metabolic and growth arrest state in response to unfavorable external environments. The nematode Caenorhabditis elegans can enter diapause/arrest during embryonic, larval, or adult stages when subjected to detrimental external environments. Larval stage 1 (L1) arrest happens when animals hatch without food. Previous work has shown that the insulin pathway plays a prominent role in regulating L1 arrest. However, the downstream signal molecular mechanisms and biomarkers are still missing. In this study, we showed that SaPosin-like Protein family member SPP-5 is significantly upregulated during L1 arrest, suggesting that it could act as an L1 arrest biomarker. Using RNA interference we demonstrated that spp-5  knockdown accelerated larval development, while the overexpression resulted in L1 arrest. Consistently, SPP-5 level was significantly up-regulated in the L1 arrest daf-2(e1370) mutants, and spp-5(RNAi) suppressed the daf-2(e1370) induced L1 arrest. These results suggest that SPP-5 can serve as an L1 arrest biomarker and promote the arrest probably via the insulin signaling pathway.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsInsulinLarvaSignal TransductionAnimalsGene Expression Regulation, DevelopmentalReceptor, InsulinRNA InterferenceCaenorhabditis elegans ProteinsInsulinReceptor, InsulinC. elegansDAF-2Developmental rateInsulin-like signaling pathwayL1 arrestSPP-5

Identifiers

PMID38869752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.