Evidence map›Paper›PMID 38869737›Full record

ArticleMolecular diversity2025

Synthesis, molecular docking and molecular dynamics simulations, drug-likeness studies, ADMET prediction and biological evaluation of novel pyrazole-carboxamides bearing sulfonamide moiety as potent carbonic anhydrase inhibitors.

İrfan Yetek, Samet Mert, Ekrem Tunca, Alpaslan Bayrakdar, Rahmi Kasımoğulları

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

İrfan YetekDepartment of Chemistry, Faculty of Arts and Sciences, Dumlupınar University, Kütahya, 43100, Türkiye.
Samet MertDepartment of Chemistry, Faculty of Arts and Sciences, Dumlupınar University, Kütahya, 43100, Türkiye.
Ekrem TuncaDepartment of Biochemistry, Faculty of Arts and Sciences, Dumlupınar University, Kütahya, 43100, Türkiye.
Alpaslan BayrakdarVocational School of Higher Education for Healthcare Services, Iğdır University, Iğdır, 76000, Türkiye.
Rahmi KasımoğullarıDepartment of Chemistry, Faculty of Arts and Sciences, Dumlupınar University, Kütahya, 43100, Türkiye. rahmi.kasimogullari@dpu.edu.tr.

Funding

Kütahya Dumlupınar University Scientific Research Projects Coordination Office 2022-02
6 · The paper itself

Abstract

Pyrazoles are unique bioactive molecules with a versatile biological profile and they have gained an important place on pharmaceutical chemistry. Pyrazole compounds containing sulfonamide nuclei also attract attention as carbonic anhydrase (CA) inhibitors. In this study, a library of pyrazole-carboxamides were synthesized and the structures of the synthesized molecules were characterized using FT-IR,

Indexed as

Carbonic Anhydrase InhibitorsMolecular Docking SimulationMolecular Dynamics SimulationPyrazolesSulfonamidesCarbonic Anhydrase ICarbonic Anhydrase IIHumansMolecular StructureStructure-Activity RelationshipCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorspyrazolePyrazolesSulfonamidesCarbonic anhydraseInhibitionMolecular dockingPyrazole-carboxamideSulfonamide

Identifiers

PMID38869737
PMCPMC11909088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.