Evidence map›Paper›PMID 38869684›Full record

ArticleEJNMMI research2024

Aurora Kinase A inhibition enhances DNA damage and tumor cell death with

Prerna Kumar, Jessica Koach, Erin Nekritz, Sucheta Mukherjee, Benjamin S Braun, Steven G DuBois, Nicole Nasholm, Daphne Haas-Kogan, Katherine K Matthay, William A Weiss and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Prerna Kumar *Department of Pediatrics, University of Illinois College of Medicine at Peoria, 530 NE Glen Oak Ave, Peoria, IL, 61637, USA. prerna@uic.edu.
Jessica Koach *Department of Pediatrics, University of California, San Francisco, CA, USA.
Erin NekritzDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Sucheta MukherjeeDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Benjamin S BraunDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Steven G DuBoisDana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Nicole NasholmDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Daphne Haas-KoganDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Katherine K MatthayDepartment of Pediatrics, University of California, San Francisco, CA, USA.
William A WeissDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Clay Gustafson *Department of Pediatrics, University of California, San Francisco, CA, USA.
Youngho Seo *Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Funding

Vascular endothelial cell integrins in angiogenesisP01CA081403 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI SEEGER, ROBERT CHARLES · 2000 to 2014
$28.5M
Shared Resource Core 2: Clinical Artificial Intelligence CoreU54CA274516 · NCI · DANA-FARBER CANCER INST · PI Ross I. Berbeco · 2023 to 2026
$8.1M
Research Training in Childhood CancerT32CA128583 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Alejandro Sweet-Cordero · 2007 to 2026
$6.0M
Pretherapy 124I-MIBG Dosimetry for Planning 131I-MIBG Neuroblastoma TherapyR01CA154561 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEO, YOUNGHO · 2011 to 2016
$1.9M
Alex's Lemonade Stand Foundation for Childhood Cancer Alex's Lemonade Stand FoundationCookies for Kids Cookies for KidsNCI NIH HHS P01 CA081403NCI NIH HHS R01 CA154561NCI NIH HHS T32 CA128583NCI NIH HHS U54 CA274516P01-CA-081403 P01-CA-081403R01CA154561 R01CA154561U54CA274516 U54CA274516
6 · The paper itself

Abstract

backgroundNeuroblastoma is the most common extra-cranial pediatric solid tumor.

resultsUsing an in vivo model of high-risk neuroblastoma, we demonstrated a marked combinatorial effect of

conclusionThe combination of AURKA inhibition with

Indexed as

131I-MIBGAurora Kinase A inhibitorsMetaiodobenzylguanidineNeuroblastomaRadiopharmaceutical

Identifiers

PMID38869684
PMCPMC11176152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.