ArticleBreast cancer research and treatment2024
The contribution of second primary cancers to the mortality of patients with a first primary breast cancer.
Article in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Risk factors for second primary cancer in patients who survive breast cancer.NPJ breast cancer · 2026Article
- Article
- Multiple Primary Cancer Incidence by County-Level Smoking Prevalence among U.S. Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- The risk of mortality from multiple primary cancers in colorectal cancer survivors: analysis of data from the South Australian Cancer Registry.Journal of cancer research and clinical oncology · 2025Article
- Discovering sequential patterns and interrelations among multiple diseases in electronic medical records using cSPADE algorithm.Archives of public health = Archives belges de sante publique · 2025Article
- A lightweight CNN for colon cancer tissue classification and visualization.Frontiers in oncology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
purposeSecond primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their diagnosis. This study aimed to estimate the contribution of SPCs to the mortality of patients with a breast first primary cancer (FPC).
methodsA population-based cohort of 17,210 patients with a breast FPC diagnosed between 2000 and 2010 was followed for SPCs (31/12/2015) and vital status (30/06/2021). Patients diagnosed with an SPC (265 synchronous and 897 metachronous, ≤ 1 and > 1 year after the FPC, respectively) were matched (1:3, by five-year age group and year of breast FPC diagnosis) to those without an SPC and alive when the corresponding SPC was diagnosed.
resultsSignificantly higher hazards of death were found among patients with an SPC [hazard ratio of 1.56, 95% confidence interval (CI) 1.29-1.89 for synchronous SPCs; and 2.85, 95%CI 2.56-3.17 for metachronous SPCs] compared to patients with a breast FPC only. Estimates were higher for synchronous lung, stomach, non-Hodgkin lymphoma and breast SPCs, and metachronous liver, stomach, ovary, lung, rectum, corpus uteri, colon, breast, and non-Hodgkin lymphoma SPCs. The 15-year cumulative mortality was 59.5% for synchronous SPCs and 68.7% for metachronous SPCs, which was higher than in patients with a breast FPC only (43.6% and 44.8%, respectively).
conclusionsIn Northern Portugal, patients with an SPC following a breast FPC have a higher mortality compared with patients with a breast FPC only.
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