ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2024
Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.
Zhanmo Ni, Prosenjit Kundu, David F McKean, William Wheeler, Demetrius Albanes, Gabriella Andreotti, Samuel O Antwi, Alan A Arslan, William R Bamlet, Laura E Beane-Freeman and 42 more
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In one paragraphArticle in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
52 authors.
Zhanmo NiDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0009-0006-9636-0482 Prosenjit KunduDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0002-4732-0314 David F McKeanDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7272-4409 Demetrius AlbanesMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-8330-4293 Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-1096-3324 Samuel O AntwiDepartment of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Jacksonville, Florida.ORCID 0000-0003-2372-9489 Alan A ArslanDepartment of Obstetrics and Gynecology, New York University School of Medicine, New York, New York.ORCID 0000-0002-7775-8085 William R BamletDepartment of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2903-1284 Laura E Beane-FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-1294-4124 Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-5230-0652 Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0001-9338-9307 Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-2324-3393 Steven GallingerLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Canada.ORCID 0000-0002-6998-9414 Edward L GiovannucciDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-6123-0219 Michael G GogginsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-4286-2296 Christopher A HaimanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-0097-9971 Manal M HassanDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-8413-449X Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0009-0000-5721-1851 Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Canada.ORCID 0000-0002-4486-7496 Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6509-6555 Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.ORCID 0000-0002-7986-8560 Peter KraftTrans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-4472-8103 Donghui LiDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-7542-0662 Steven C MooreMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-8169-1661 Rachel E NealeDepartment of Population Health, QIMR Berghofer Medical Research Institute, Queensland, Australia.ORCID 0000-0001-7162-0854 Ann L ObergDepartment of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2539-9807 Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0001-5666-9318 Kari G RabeDepartment of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0002-7313-1875 Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.ORCID 0000-0001-5337-3941 Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-0711-8314 Karl Smith-ByrneCancer Epidemiology Unit, The Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-1932-7463 Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0002-0582-8005 Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York.ORCID 0000-0003-3096-9595 Emily WhiteDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0003-0544-1633 Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, New York.ORCID 0000-0001-9350-1303 Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0003-1226-070X Jun ZhongLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-3700-9434 Laufey T AmundadottirLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-1859-8971 Rachael Z Stolzenberg-Solomon *Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-3698-7006 Alison P Klein *Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0003-2737-8399 Funding
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
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$83.1MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI THOMPSON, ELIZABETH D · 1993 to 2022
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$22.3MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
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$15.8MPhysicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
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6 · The paper itselfAbstract
backgroundPancreatic cancer is a leading cause of cancer-related death globally. Risk factors for pancreatic cancer include common genetic variants and potentially heavy alcohol consumption. We assessed if genetic variants modify the association between heavy alcohol consumption and pancreatic cancer risk.
methodsWe conducted a genome-wide interaction analysis of single-nucleotide polymorphisms (SNP) by heavy alcohol consumption (more than three drinks per day) for pancreatic cancer in European ancestry populations from genome-wide association studies. Our analysis included 3,707 cases and 4,167 controls from case-control studies and 1,098 cases and 1,162 controls from cohort studies. Fixed-effect meta-analyses were conducted.
resultsA potential novel region of association on 10p11.22, lead SNP rs7898449 (interaction P value (Pinteraction) = 5.1 × 10-8 in the meta-analysis; Pinteraction = 2.1 × 10-9 in the case-control studies; Pinteraction = 0.91 in the cohort studies), was identified. An SNP correlated with this lead SNP is an expression quantitative trait locus for the neuropilin 1 gene. Of the 17 genomic regions with genome-wide significant evidence of association with pancreatic cancer in prior studies, we observed suggestive evidence that heavy alcohol consumption modified the association for one SNP near LINC00673, rs11655237 on 17q25.1 (Pinteraction = 0.004).
conclusionsWe identified a novel genomic region that may be associated with pancreatic cancer risk in conjunction with heavy alcohol consumption located near an expression quantitative trait locus for neuropilin 1, a protein that plays an important role in the development and progression of pancreatic cancer. IMPACT: This work can provide insights into the etiology of pancreatic cancer, particularly in heavy drinkers.
Indexed as
Alcohol DrinkingGenome-Wide Association StudyPancreatic NeoplasmsPolymorphism, Single NucleotideCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedRisk Factors
Identifiers
PMID38869494
PMCPMC11928872
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