Evidence map›Paper›PMID 38869353›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Decreased Liver Kinase B1 Expression and Impaired Angiogenesis in a Murine Model of Bronchopulmonary Dysplasia.

Ujala Rana, Chintamani Joshi, Elijah Whitney, Adeleye Afolayan, Jasmine Dowell, Ru-Jeng Teng, Girija G Konduri

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05853601 phase1 / phase2active not recruitingnot on this map

Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage

TypeinterventionalSponsorMedical College of WisconsinRan2023 to 2027Enrolled30ConditionsAcute Kidney Injury, HIEArmsSingle Dose Theophylline, Repeat Dose Theophylline
NCT07120971 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase 0/Phase 1 Trial of Metformin for Premature Infants With Bronchopulmonary Dysplasia

TypeinterventionalSponsorMedical College of WisconsinRan2025 to 2030Enrolled40ConditionsBronchopulmonary Dysplasia (BPD)ArmsMetformin (open-label)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Metformin Promotes Angiogenesis in Neonatal Lung Injury: A New Deal of an Old Drug.American journal of respiratory cell and molecular biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ujala RanaNeonatology Division, Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin.
Chintamani JoshiNeonatology Division, Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin.
Elijah WhitneyNeonatology Division, Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin.
Adeleye AfolayanNeonatology Division, Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0001-9886-6694
Jasmine DowellNeonatology Division, Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin.
Ru-Jeng TengNeonatology Division, Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0003-4321-2452
Girija G KonduriNeonatology Division, Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-3602-1538

Funding

Role of Liver Kinase B1 in the decreased angiogenesis in bronchopulmonary dysplasiaR01HL174635 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GIRIJA G. KONDURI · 2024 to 2026
$1.9M
AMP Kinase regulation in persistent pulmonary hypertension of the newbornR01HL136597 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI KONDURI, GIRIJA G. · 2018 to 2021
$1.5M
Advancing a Healthier Wisconsin EndowmentNHLBI NIH HHS R01 HL136597NHLBI NIH HHS R01 HL174635
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is characterized by impaired lung alveolar and vascular growth. We investigated the hypothesis that neonatal exposure to hyperoxia leads to persistent BPD phenotype caused by decreased expression of liver kinase B1 (LKB1), a key regulator of mitochondrial function. We exposed mouse pups from Postnatal Day (P)1 through P10 to 21% or 75% oxygen. Half of the pups in each group received metformin or saline intraperitoneally from P1 to P10. Pups were killed at P4 or P10 or recovered in 21% O

Indexed as

Bronchopulmonary DysplasiaDisease Models, AnimalHyperoxiaProtein Serine-Threonine KinasesAMP-Activated Protein KinasesAngiogenesisAnimalsAnimals, NewbornEndothelial CellsHumansLungMetforminMiceMice, Inbred C57BLNeovascularization, PathologicNeovascularization, PhysiologicAMP-Activated Protein KinasesMetforminProtein Serine-Threonine KinasesStk11 protein, mousealveolarizationAMP kinasemitochondrial functionPGC-1αprematurity

Identifiers

PMID38869353
PMCPMC12392931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.