Evidence map›Paper›PMID 38869304›Full record

ReviewJournal of bacteriology2024

Guarding the walls: the multifaceted roles of Bce modules in cell envelope stress sensing and antimicrobial resistance.

Natasha L George, Ellen C Bennett, Benjamin J Orlando

Abstract readReview
In one paragraph

Review in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. LiaS-dependent activation of the MadR regulon enables cross-talk betweenbioRxiv : the preprint server for biology · 2025
    Article
  5. International journal of systematic and evolutionary microbiology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natasha L GeorgeDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.
Ellen C BennettDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.
Benjamin J OrlandoDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-7079-8140

Funding

Structural Basis of Antimicrobial Peptide Sensing and ResistanceR35GM146721 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Benjamin Joseph Orlando · 2022 to 2026
$1.9M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM146721NIGMS NIH HHS R35 GM146721
6 · The paper itself

Abstract

Bacteria have developed diverse strategies for defending their cell envelopes from external threats. In Firmicutes, one widespread strategy is to use Bce modules-membrane protein complexes that unite a peptide-detoxifying ABC transporter with a stress response coordinating two-component system. These modules provide specific, front-line defense for a wide variety of antimicrobial peptides and small molecule antibiotics as well as coordinate responses for heat, acid, and oxidative stress. Because of these abilities, Bce modules play important roles in virulence and the development of antibiotic resistance in a variety of pathogens, including

Indexed as

Bacterial ProteinsCell WallDrug Resistance, BacterialAnti-Bacterial AgentsATP-Binding Cassette TransportersBacillus subtilisCell MembraneGene Expression Regulation, BacterialStress, PhysiologicalAnti-Bacterial AgentsATP-Binding Cassette TransportersBacterial ProteinsantimicrobialBcekinaseresistancetransporter

Identifiers

PMID38869304
PMCPMC11270860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.