Evidence map›Paper›PMID 38869284›Full record

ArticleJournal of virology2024

Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria.

Shannon C David, Aline Schaub, Céline Terrettaz, Ghislain Motos, Laura J Costa, Daniel S Nolan, Marta Augugliaro, Htet Kyi Wynn, Irina Glas, Marie O Pohl and 10 more

Erratum issuedAbstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Shannon C DavidLaboratory of Environmental Virology, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0003-3345-9443
Aline SchaubLaboratory of Environmental Virology, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Céline TerrettazLaboratory of Environmental Virology, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Ghislain MotosLaboratory of Atmospheric Processes and their Impacts, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Laura J CostaLaboratory of Environmental Virology, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Daniel S NolanLaboratory of Environmental Virology, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Marta AugugliaroInstitute for Atmospheric and Climate Science, ETH Zürich, Zürich, Switzerland.
Htet Kyi WynnLaboratory of Environmental Virology, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Irina GlasInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.ORCID 0000-0001-6976-6360
Marie O PohlInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.
Liviana K KleinInstitute for Atmospheric and Climate Science, ETH Zürich, Zürich, Switzerland.
Beiping LuoInstitute for Atmospheric and Climate Science, ETH Zürich, Zürich, Switzerland.
Nir BluvshteinInstitute for Atmospheric and Climate Science, ETH Zürich, Zürich, Switzerland.
Kalliopi ViolakiLaboratory of Atmospheric Processes and their Impacts, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Walter HugentoblerLaboratory of Atmospheric Processes and their Impacts, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Ulrich K KriegerInstitute for Atmospheric and Climate Science, ETH Zürich, Zürich, Switzerland.
Thomas PeterInstitute for Atmospheric and Climate Science, ETH Zürich, Zürich, Switzerland.
Silke StertzInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.ORCID 0000-0001-9491-2892
Athanasios NenesLaboratory of Atmospheric Processes and their Impacts, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Tamar KohnLaboratory of Environmental Virology, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0003-0395-6561

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 189939Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 209808
6 · The paper itself

Abstract

Aerosol transmission remains a major challenge for control of respiratory viruses, particularly those causing recurrent epidemics, like influenza A virus (IAV). These viruses are rarely expelled alone, but instead are embedded in a consortium of microorganisms that populate the respiratory tract. The impact of microbial communities and inter-pathogen interactions upon stability of transmitted viruses is well-characterized for enteric pathogens, but is under-studied in the respiratory niche. Here, we assessed whether the presence of five different species of commensal respiratory bacteria could influence the persistence of IAV within phosphate-buffered saline and artificial saliva droplets deposited on surfaces at typical indoor air humidity, and within airborne aerosol particles. In droplets, presence of individual species or a mixed bacterial community resulted in 10- to 100-fold more infectious IAV remaining after 1 h, due to bacterial-mediated flattening of drying droplets and early efflorescence. Even when no efflorescence occurred at high humidity or the bacteria-induced changes in droplet morphology were abolished by aerosolization instead of deposition on a well plate, the bacteria remained protective.

Indexed as

AerosolsInfluenza A virusAnimalsBacteriaDogsHumansInfluenza, HumanMadin Darby Canine Kidney CellsMicrobiotaRespiratory SystemStaphylococcus aureusStreptococcus pneumoniaeSymbiosisAerosolsaerosolaerovirologydropletinfluenza A virusrespiratory microbiotasaliva

Identifiers

PMID38869284
PMCPMC11264603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.