Evidence map›Paper›PMID 38868771›Full record

ReviewFrontiers in immunology2024

Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy.

Naimah Turner, Sarah Hamidi, Rim Ouni, Rene Rico, Ying C Henderson, Maria Puche, Sayan Alekseev, Jocelynn G Colunga-Minutti, Mark E Zafereo, Stephen Y Lai and 3 more

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Naimah Turner *Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Sarah Hamidi *Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Rim OuniDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Rene RicoDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Ying C HendersonDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Maria PucheDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Sayan AlekseevDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Jocelynn G Colunga-MinuttiDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Mark E ZafereoDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Stephen Y LaiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Sang T KimDepartment of Rheumatology, Allergy and Immunology, Yale University, New Haven, CT, United States.
Maria E CabanillasDepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Roza NurievaDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Funding

UPWARDS Training Program (Underrepresented Minorities Working Towards Research Diversity in Science)R25CA240137 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KEYOMARSI, KHANDAN, WATOWICH, STEPHANIE S · 2020 to 2024
$2.1M
Role of E3 Ubiquitin ligase RNF133 in T cell function and toleranceR01HL141966 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2019 to 2022
$1.6M
Role of Cul4A in Governing Th2-Type ToleranceR01HL143520 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2018 to 2021
$1.6M
Mechanism-rooted therapeutic strategies for immune-related toxicities induced by checkpoint inhibitorsR01CA284684 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Roza Insafetdinovna Nurieva · 2023 to 2026
$1.5M
NCI NIH HHS R01 CA284684NCI NIH HHS R25 CA240137NHLBI NIH HHS R01 HL141966NHLBI NIH HHS R01 HL143520
6 · The paper itself

Abstract

Although most follicular-derived thyroid cancers are well differentiated and have an overall excellent prognosis following treatment with surgery and radioiodine, management of advanced thyroid cancers, including iodine refractory disease and poorly differentiated/undifferentiated subtypes, is more challenging. Over the past decade, better understanding of the genetic drivers and immune milieu of advanced thyroid cancers has led to significant progress in the management of these patients. Numerous targeted kinase inhibitors are now approved by the U.S Food and Drug administration (FDA) for the treatment of advanced, radioiodine refractory differentiated thyroid cancers (DTC) as well as anaplastic thyroid cancer (ATC). Immunotherapy has also been thoroughly studied and has shown promise in selected cases. In this review, we summarize the progress in the understanding of the genetic landscape and the cellular and molecular basis of radioiodine refractory-DTC and ATC, as well as discuss the current treatment options and future therapeutic avenues.

Indexed as

Adenocarcinoma, FollicularImmunotherapyAnimalsHumansIodine RadioisotopesProtein Kinase InhibitorsThyroid NeoplasmsIodine RadioisotopesProtein Kinase Inhibitorsimmunotherapymutational landscapetargeted therapythyroid cancertumor immune microenvironment

Identifiers

PMID38868771
PMCPMC11167082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.