Evidence map›Paper›PMID 38868513›Full record

ArticleiMeta2024

CBD2: A functional biomarker database for colorectal cancer.

Xueli Zhang, Min Li, Siting Ye, Ke Shen, Haining Yuan, Shoaib Bakhtyar, Qiliang Peng, Yongsheng Liu, Yingying Wang, Manshi Li and 10 more

Abstract read
In one paragraph

Article in iMeta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xueli ZhangMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Min LiMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.ORCID 0009-0003-9757-6822
Siting YeDepartment of Ultrasound The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China.
Ke ShenDepartment of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital Sichuan University Chengdu China.
Haining YuanSchool of Laboratory Medicine and Bioengineering Hangzhou Medical College Hangzhou China.
Shoaib BakhtyarSchool of Medicine, Institute of Medical Sciences Örebro University Örebro Sweden.
Qiliang PengDepartment of Radiotherapy and Oncology The Second Affiliated Hospital of Soochow University Suzhou China.
Yongsheng LiuDepartment of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden.
Yingying WangKey Laboratory of Public Health Safety, School of Public Health Fudan University Shanghai China.ORCID 0000-0002-8426-4526
Manshi LiKey Laboratory of Public Health Safety, School of Public Health Fudan University Shanghai China.
Chi ZhangDepartment of Otolaryngology Guangzhou Women and Children's Medical Centre Guangzhou China.
Yixin WangMOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow University Suzhou China.
Xiaohe BaiDepartment of Mathematics University of California San Diego California USA.
Shunming LiuDepartment of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Eye Institute Southern Medical University Guangzhou China.
Ke ZhaoMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Bairong ShenInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital Sichuan University Chengdu China.
Dirk RepsilberSchool of Medicine, Institute of Medical Sciences Örebro University Örebro Sweden.
Guang HuMOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine, Department of Bioinformatics, Center for Systems Biology, School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow University Suzhou China.
Hong ZhangSchool of Medicine, Institute of Medical Sciences Örebro University Örebro Sweden.
Xiao-Feng SunDepartment of Oncology and Department of Biomedical and Clinical Sciences Linköping University Linköping Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapidly evolving landscape of biomarkers for colorectal cancer (CRC) necessitates an integrative, updated repository. In response, we constructed the Colorectal Cancer Biomarker Database (CBD), which collected and displayed the curated biomedicine information for 870 CRC biomarkers in the previous study. Building on CBD, we have now developed CBD2, which includes information on 1569 newly reported biomarkers derived from different biological sources (DNA, RNA, protein, and others) and clinical applications (diagnosis, treatment, and prognosis). CBD2 also incorporates information on nonbiomarkers that have been identified as unsuitable for use as biomarkers in CRC. A key new feature of CBD2 is its network analysis function, by which users can investigate the visible and topological network between biomarkers and identify their relevant pathways. CBD2 also allows users to query a series of chemicals, drug combinations, or multiple targets, to enable multidrug, multitarget, multipathway analyses, toward facilitating the design of polypharmacological treatments for CRC. CBD2 is freely available at http://www.eyeseeworld.com/cbd.

Indexed as

biomarkercolorectal cancerdatabasenetwork analysis

Identifiers

PMID38868513
PMCPMC10989088

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.