Evidence map›Paper›PMID 38868198›Full record

ArticleiScience2024

Expression of GAD2 in excitatory neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleus.

Erika K Harding, Zizhen Zhang, Julia Canet-Pons, Sierra Stokes-Heck, Tuan Trang, Gerald W Zamponi

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erika K HardingDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB T2N 4N1, Canada.
Zizhen ZhangDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB T2N 4N1, Canada.
Julia Canet-PonsFaculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Sierra Stokes-HeckFaculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Tuan TrangFaculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Gerald W ZamponiDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB T2N 4N1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ventrolateral periaqueductal gray (vlPAG) functionally projects to diverse brain regions, including the locus coeruleus (LC). Excitatory projections from the vlPAG to the LC are well described, while few studies have indicated the possibility of inhibitory projections. Here, we quantified the relative proportion of excitatory and inhibitory vlPAG-LC projections in male and female mice, and found an unexpected overlapping population of neurons expressing both GAD2 and VGLUT2. Combined

Indexed as

Biological sciencesCell biologyMolecular neuroscienceNeuroscience

Identifiers

PMID38868198
PMCPMC11166693

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.