Evidence map›Paper›PMID 38868190›Full record

ArticleiScience2024

Machine-learning-based integrative -'omics analyses reveal immunologic and metabolic dysregulation in environmental enteric dysfunction.

Fatima Zulqarnain, Xueheng Zhao, Kenneth D R Setchell, Yash Sharma, Phillip Fernandes, Sanjana Srivastava, Aman Shrivastava, Lubaina Ehsan, Varun Jain, Shyam Raghavan and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Fatima ZulqarnainUniversity of Virginia, Charlottesville, VA, USA.
Xueheng ZhaoCincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Kenneth D R SetchellCincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Yash SharmaUniversity of Virginia, Charlottesville, VA, USA.
Phillip FernandesUniversity of Virginia, Charlottesville, VA, USA.
Sanjana SrivastavaUniversity of Virginia, Charlottesville, VA, USA.
Aman ShrivastavaUniversity of Virginia, Charlottesville, VA, USA.
Lubaina EhsanUniversity of Virginia, Charlottesville, VA, USA.
Varun JainUniversity of Virginia, Charlottesville, VA, USA.
Shyam RaghavanUniversity of Virginia, Charlottesville, VA, USA.
Christopher MoskalukUniversity of Virginia, Charlottesville, VA, USA.
Yael HabermanCincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Lee A DensonCincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Khyati MehtaCincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Najeeha T IqbalAga Khan University, Karachi, Pakistan.
Najeeb RahmanAga Khan University, Karachi, Pakistan.
Kamran SadiqAga Khan University, Karachi, Pakistan.
Zubair AhmadAga Khan University, Karachi, Pakistan.
Romana IdressAga Khan University, Karachi, Pakistan.
Junaid IqbalAga Khan University, Karachi, Pakistan.
Sheraz AhmedAga Khan University, Karachi, Pakistan.
Aneeta HotwaniAga Khan University, Karachi, Pakistan.
Fayyaz UmraniAga Khan University, Karachi, Pakistan.
Beatrice AmadiUniversity Teaching Hospital, Lusaka, Zambia.
Paul KellyUniversity Teaching Hospital, Lusaka, Zambia.
Donald E BrownUniversity of Virginia, Charlottesville, VA, USA.
Sean R MooreUniversity of Virginia, Charlottesville, VA, USA.
Syed Asad AliAga Khan University, Karachi, Pakistan.
Sana SyedUniversity of Virginia, Charlottesville, VA, USA.

Funding

Computational Characterization of Environmental EnteropathyK23DK117061 · NIDDK · UNIVERSITY OF VIRGINIA · PI SYED, SANA · 2019 to 2023
$964k
Global Lipidomics Analysis Techniques for Novel Biomarker Discovery of Environmental EnteropathyF31DK131885 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI MEHTA, KHYATI · 2022 to 2023
$62k
NIDDK NIH HHS F31 DK131885NIDDK NIH HHS K23 DK117061
6 · The paper itself

Abstract

Environmental enteric dysfunction (EED) is a subclinical enteropathy challenging to diagnose due to an overlap of tissue features with other inflammatory enteropathies. EED subjects (

Indexed as

GastroenterologyLipidomicsMachine learningMedical imagingMetabolic flux analysisTranscriptomics

Identifiers

PMID38868190
PMCPMC11167436

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.