Evidence map›Paper›PMID 38868181›Full record

ArticleiScience2024

Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition.

Ronan C Bracken, Lindsay M Davison, Dennis P Buehler, Maci E Fulton, Emily E Carson, Quanhu Sheng, Lindsey K Stolze, Christelle Guillermier, Matthew L Steinhauser, Jonathan D Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ronan C BrackenDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Lindsay M DavisonDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Dennis P BuehlerDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Maci E FultonDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Emily E CarsonDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Quanhu ShengDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Lindsey K StolzeDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Christelle GuillermierHarvard Medical School, Boston, MA 02115, USA.
Matthew L SteinhauserAging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Jonathan D BrownDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Funding

Elucidating the chromatin-dependent mechanisms governing chronic inflammatory activation of endothelial cells in atherosclerosis.R01HL146654 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BROWN, JONATHAN DAVID · 2020 to 2023
$2.4M
NHLBI NIH HHS R01 HL146654
6 · The paper itself

Abstract

Combinatorial signaling by proinflammatory cytokines synergizes to exacerbate toxicity to cells and tissue injury during acute infections. To explore synergism at the gene-regulatory level, we investigated the dynamics of transcription and chromatin signaling in response to dual cytokines by integrating nascent RNA imaging mass spectrometry, RNA sequencing, amplification-independent mRNA quantification, assay for transposase-accessible chromatin using sequencing (ATAC-seq), and transcription factor profiling. Costimulation with interferon-gamma (IFNγ) and tumor necrosis factor alpha (TNFα) synergistically induced a small subset of genes, including the chemokines

Indexed as

Cell biologyChemogenomicsComponents of the immune systemGenomicsSystems biologyTranscriptomics

Identifiers

PMID38868181
PMCPMC11167439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.