Evidence map›Paper›PMID 38868068›Full record

ArticleHeliyon2024

Unraveling sleep respiratory dysfunction in amyotrophic lateral sclerosis: Beyond the apnea-hypopnea index and sleep-related hypoxia.

Andi Nuredini, Dario Bottignole, Filippo Stragliati, Pietro Anceschi, Sonia Romano, Irene Pollara, Anna Abramo, Francesco Rausa, Liborio Parrino, Lucia Zinno and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Uncoupling of apnea-hypopnea index and oxygen desaturation in als: characterization and diagnostic implications of an "AHI-SpO₂ dissociation" phenotype.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andi NurediniUnit of Neurosciences, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Dario BottignoleUnit of Neurosciences, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Filippo StragliatiUnit of Neurosciences, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Pietro AnceschiUnit of Neurosciences, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Sonia RomanoUnit of Neurosciences, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Irene PollaraSleep Disorders Center, Department of General and Specialized Medicine, University Hospital of Parma, Parma, Italy.
Anna AbramoSleep Disorders Center, Department of General and Specialized Medicine, University Hospital of Parma, Parma, Italy.
Francesco RausaSleep Disorders Center, Department of General and Specialized Medicine, University Hospital of Parma, Parma, Italy.
Liborio ParrinoUnit of Neurosciences, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Lucia ZinnoNeurology Unit, Department of General and Specialized Medicine, University Hospital of Parma, Parma, Italy.
Carlotta MuttiSleep Disorders Center, Department of General and Specialized Medicine, University Hospital of Parma, Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The timely introduction of non-invasive ventilation (NIV) is extremely relevant in the multidisciplinary management of patients affected by amyotrophic lateral sclerosis (ALS) and is based on the proper identification of red flags for early diaphragmatic exhaustion. Polygraphic sleep recording may provide insightful information on the ongoing respiratory impairment; in particular, atypical breathing patterns need to be recognized, as the application of current guidelines for sleep-related hypoxemia or sleep apnea may be insufficient for detecting early signs of diaphragmatic fatigue. We report the case of a 51-year-old man affected by ALS who was asymptomatic for breathing impairment, but whose nocturnal polysomnographic recording, despite not significant for obstructive sleep apnea nor for conventional hypoventilatory patterns, strongly suggested initial respiratory failure, as lately confirmed by the pulmonary follow-up. We discuss the advantages of including sleep recording in the clinical work-up of patients affected by ALS.

Indexed as

Amyotrophic lateral sclerosisDiagnosisHypoventilationNoninvasive ventilationSleep recording

Identifiers

PMID38868068
PMCPMC11168423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.