Evidence map›Paper›PMID 38867880›Full record

ArticleJournal of the Endocrine Society2024

The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study.

Katharina Warncke, Roy Tamura, Desmond A Schatz, Riitta Veijola, Andrea K Steck, Beena Akolkar, William Hagopian, Jeffrey P Krischer, Åke Lernmark, Marian J Rewers and 6 more

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In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Katharina WarnckeTUM School of Medicine, Department of Pediatrics, Technical University of Munich, 81675 Munich, Germany.ORCID https://orcid.org/0000-0003-1758-7656
Roy TamuraHealth Informatics Institute, University of South Florida, Tampa, FL 33612, USA.
Desmond A SchatzDiabetes Center of Excellence, University of Florida, Gainesville, FL 32610, USA.
Riitta VeijolaDepartment of Pediatrics, Research Unit of Clinical Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014 Oulu, Finland.
Andrea K SteckBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0002-5931-9484
Beena AkolkarNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
William HagopianDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jeffrey P KrischerHealth Informatics Institute, University of South Florida, Tampa, FL 33612, USA.ORCID https://orcid.org/0000-0003-4526-888X
Åke LernmarkDepartment of Clinical Sciences, Lund University/Clinical Research Centre, Skane University Hospital, 21428 Malmö, Sweden.
Marian J RewersBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jorma ToppariDepartment of Pediatrics, University of Turku and Turku University Hospital, 20520 Turku, Finland.
Richard McIndoeCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Anette-G ZieglerGerman Center for Environmental Health, Institute of Diabetes Research, Helmholtz Munich, 80939 Munich, Germany.
Kendra VehikHealth Informatics Institute, University of South Florida, Tampa, FL 33612, USA.ORCID https://orcid.org/0000-0001-6243-6772
Michael J HallerDepartment of Pediatrics, Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Helena Elding LarssonUnit for Pediatric Endocrinology, Department of Clinical Sciences Malmö, Lund University, 20502 Malmö, Sweden.

Funding

Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)U01DK128847 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI JEFFREY P KRISCHER · 2021 to 2026
$79.2M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
NCATS NIH HHS UL1 TR002535NIDDK NIH HHS U01 DK128847
6 · The paper itself

Abstract

Context: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty. Objective: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes. Methods: The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Onset of puberty was determined by subject self-assessment of Tanner stages. Associations between speed of pubertal progression, pubertal growth, weight gain, homeostasis model assessment of insulin resistance (HOMA-IR), islet autoimmunity, and progression to type 1 diabetes were assessed. The influence of individual factors was analyzed using Cox proportional hazard ratios. Results: Out of 5677 children who were still in the study at age 8 years, 95% reported at least 1 Tanner Stage score and were included in the study. Children at puberty (Tanner Stage ≥2) had a lower risk (HR 0.65, 95% CI 0.45-0.93; Conclusion: Rapid weight gain during puberty is associated with development of islet autoimmunity. Puberty itself had no significant influence on the appearance of autoantibodies or type 1 diabetes. Further studies are needed to better understand the underlying mechanisms.

Indexed as

diabetesinsulin resistancetype 1 diabetesβ-cell

Identifiers

PMID38867880
PMCPMC11167566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.