Evidence map›Paper›PMID 38867767›Full record

ArticleBiomedical optics express2024

In vivo quantitative characterization of nano adjuvant transport in the tracheal layer by photoacoustic imaging.

Chaohao Liang, Fan Meng, Yiqing Zhang, Yuxiang Chen, Li Luo, Hongyan Li, Xinbo Tu, Fengbing He, Zhijia Luo, Qian Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chaohao LiangSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Fan MengSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Yiqing ZhangSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Yuxiang ChenSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Li LuoSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Hongyan LiSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Xinbo TuSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Fengbing HeSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Zhijia LuoSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Qian WangSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Jian ZhangSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.ORCID https://orcid.org/0000-0002-9665-9322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adjuvants are indispensable ingredients in vaccine formulations. Evaluating the in vivo transport processes of adjuvants, particularly for inhalation formulations, presents substantial challenges. In this study, a nanosized adjuvant aluminum hydroxide (AlOOH) was synthesized and labeled with indocyanine green (ICG) and bovine serum albumin (BSA) to achieve strong optical absorption ability and high biocompatibility. The adjuvant nanomaterials (BSA@ICG@AlOOH, BIA) were delivered as an aerosol into the airways of mice, its distribution was monitored using photoacoustic imaging (PAI) in vivo. PAI results illustrated the gradual cross-layer transmission process of BIA in the tracheal layer, traversing approximately 250 µm from the inner layer of the trachea to the outer layer. The results were consistent with pathology. While the intensity of the BIA reduced by approximately 46.8% throughout the transport process. The ability of PAI for quantitatively characterized the dynamic transport process of adjuvant within the tracheal layer may be widely used in new vaccine development.

Identifiers

PMID38867767
PMCPMC11166438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.