ArticleiMeta2022
Dietary licorice enhances in vivo cadmium detoxification and modulates gut microbial metabolism in mice.
Article in iMeta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
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- Sequence-based Functional Metagenomics Reveals Novel Natural Diversity of Functional CopA in Environmental Microbiomes.Genomics, proteomics & bioinformatics · 2023Article
- Intraspecific difference ofiMeta · 2023Article
- Docosahexaenoic Acid Promotes Cd Excretion by Restoring the Abundance ofMolecules (Basel, Switzerland) · 2023Article
- New insights into the mechanisms of high-fat diet mediated gut microbiota in chronic diseases.iMeta · 2023Review
- Correction.iMeta · 2022Article
- Article
- Dietary licorice enhances in vivo cadmium detoxification and modulates gut microbial metabolism in mice.iMeta · 2022Article
Corrections and comments
- Erratum issuedCorrection.2022
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mass cadmium (Cd) poisoning is a serious health problem in many parts of the world. We propose that dietary intervention can be a practical solution to this problem. This study aimed to identify effective dietary products from traditional Chinese herbs that can detoxify Cd. Five candidate herbal foods with detoxifying potential were selected and subjected to mouse toxicological tests. The chemical composition and dose-response effects of licorice on mouse hepatocytes were determined. Licorice was selected for further tests to examine its effects on growth, tissue Cd accumulation, and gut and liver fitness of mice. The expression of hepatic metallothionein (Mt) genes was quantified in vitro in hepatocytes and in vivo in liver tissues of mice. The results showed that licorice dietary intervention was effective in reducing blood Cd by >50% within 1 month. Cd was also substantially reduced in the heart and lung tissues, but increased 2.1-fold in the liver. The liver of Cd poisoned mice improved with licorice intervention. Licorice treatment significantly induced Cd accumulation and expression of the
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