Evidence map›Paper›PMID 38867486›Full record

ArticleCell transplantation

Efficacy of Neonatal Porcine Bone Marrow-Derived Mesenchymal Stem Cell Xenotransplantation for the Therapy of Hind Limb Lymphedema in Mice.

Yuichi Morita, Naoaki Sakata, Masuhiro Nishimura, Ryo Kawakami, Masayuki Shimizu, Gumpei Yoshimatsu, Osamu Sawamoto, Shinichi Matsumoto, Hideichi Wada, Shohta Kodama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuichi MoritaDepartment of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Naoaki SakataDepartment of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.ORCID 0000-0002-3495-4270
Masuhiro NishimuraResearch and Development Center, Otsuka Pharmaceutical Factory, Inc., Naruto, Japan.ORCID 0000-0003-3737-704X
Ryo KawakamiDepartment of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Masayuki ShimizuDepartment of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Gumpei YoshimatsuDepartment of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Osamu SawamotoResearch and Development Center, Otsuka Pharmaceutical Factory, Inc., Naruto, Japan.ORCID 0000-0002-1756-8829
Shinichi MatsumotoResearch and Development Center, Otsuka Pharmaceutical Factory, Inc., Naruto, Japan.
Hideichi WadaDepartment of Cardiovascular Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Shohta KodamaDepartment of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.ORCID 0000-0002-9571-342X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphedema is an intractable disease with few effective therapeutic options. Autologous mesenchymal stem cell (MSC) transplantation is a promising therapy for this disease. However, its use is limited by the cost and time for preparation. Recently, xenotransplantation of porcine MSCs has emerged as an alternative to autologous MSC transplantation. In this study, we aimed to clarify the usefulness of neonatal porcine bone marrow-derived MSC (NpBM-MSC) xenotransplantation for the treatment of lymphedema. One million NpBM-MSCs were xenotransplanted into the hind limbs of mice with severe lymphedema (MSC transplantation group). The therapeutic effects were assessed by measuring the femoral circumference, the volume of the hind limb, the number and diameter of lymphatic vessels in the hind limb, and lymphatic flow using a near-infrared fluorescence (NIRF) imaging system. We compared the effects using mice with lymphedema that did not undergo NpBM-MSC transplantation (negative control group). The condition of the transplanted NpBM-MSCs was also evaluated histologically. The femoral circumference and volume of the hind limb had been normalized by postoperative day (POD) 14 in the MSC transplantation group, but not in the negative control group (

Indexed as

HindlimbLymphedemaMesenchymal Stem CellsMesenchymal Stem Cell TransplantationTransplantation, HeterologousAnimalsAnimals, NewbornBone Marrow CellsLymphatic VesselsMiceSwinelymphangiogenesislymphedemamesenchymal stem cellMSCpigvascular endothelial growth factorVEGFxenotransplantation

Identifiers

PMID38867486
PMCPMC11179447

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.