Evidence map›Paper›PMID 38867362›Full record

ArticlePsychiatry and clinical neurosciences2024

Habenular volume changes after venlafaxine treatment in patients with major depression.

Josselin Etienne, Alexandre Boutigny, Denis J David, Eric Deflesselle, Florence Gressier, Laurent Becquemont, Emmanuelle Corruble, Romain Colle

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry and clinical neurosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02051413 (Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02051413 phase4completednot on this map

Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder

TypeinterventionalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2014 to 2018Enrolled67ConditionsMajor Depressive Disorder, Major Depressive EpisodeArmsVenlafaxine extended release
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Josselin EtienneService Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Alexandre BoutignyEquipe Moods, INSERM UMR-1178, CESP, Université Paris-Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.
Denis J DavidEquipe Moods, INSERM UMR-1178, CESP, Université Paris-Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.
Eric DeflesselleEquipe Moods, INSERM UMR-1178, CESP, Université Paris-Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.
Florence GressierService Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.ORCID https://orcid.org/0000-0002-5160-9823
Laurent BecquemontEquipe Moods, INSERM UMR-1178, CESP, Université Paris-Saclay, Faculté de Médecine, Le Kremlin Bicêtre, France.
Emmanuelle CorrubleService Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Romain ColleService Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.ORCID https://orcid.org/0000-0002-2549-4495

Funding

ANR SAMENTA 2012 C13-25ANR SAMENTA 2012 EudraCT 2013-004326-29
6 · The paper itself

Abstract

backgroundHabenula, a hub brain region controlling monoaminergic brain center, has been implicated in major depressive disorder (MDD) and as a possible target of antidepressant response. Nevertheless, the effect of antidepressant drug treatment on habenular volumes remains unknown. The objective of the present research was to study habenular volume change after antidepressant treatment in patients with MDD, and assess whether it is associated with clinical improvement.

methodsFifty patients with a current major depressive episode (MDE) in the context of MDD, and antidepressant-free for at least 1 month, were assessed for habenula volume (3T MRI with manual segmentation) before and after a 3 months sequence of venlafaxine antidepressant treatment.

resultsA 2.3% significant increase in total habenular volume (absolute volume: P = 0.0013; relative volume: P = 0.0055) and a 3.3% significant increase in left habenular volume (absolute volume: P = 0.00080; relative volume: P = 0.0028) were observed. A significant greater variation was observed in male patients (4.8%) compared to female patients. No association was observed between habenular volume changes and response and remission. Some habenula volume changes were associated with improvement of olfactory pleasantness.

conclusionHabenular volumes increased after 3 months of venlafaxine treatment in depressed patients. Further studies should assess whether cell proliferation and density or dendritic structure variations are implied in these volume changes.

Indexed as

HabenulaMagnetic Resonance ImagingMajor Depressive DisorderVenlafaxine HydrochlorideAdultAntidepressive Agents, Second-GenerationFemaleHumansMaleMiddle AgedAntidepressive Agents, Second-GenerationVenlafaxine Hydrochlorideaffective disordersneuroimaging in psychiatrypharmacopsychiatrypsychoneurobiology

Identifiers

PMID38867362
PMCPMC11488621

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.