Evidence map›Paper›PMID 38867250›Full record

ArticleSkeletal muscle2024

Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice.

Urszula Florczyk-Soluch, Katarzyna Polak, Sarka Jelinkova, Iwona Bronisz-Budzyńska, Reece Sabo, Subhashini Bolisetty, Anupam Agarwal, Ewa Werner, Alicja Józkowicz, Jacek Stępniewski and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Urszula Florczyk-SoluchDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland. urszula.florczyk@uj.edu.pl.
Katarzyna PolakDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Sarka JelinkovaDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Iwona Bronisz-BudzyńskaDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Reece SaboDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Subhashini BolisettyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Anupam AgarwalDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ewa WernerDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Alicja JózkowiczDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Jacek StępniewskiDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Krzysztof SzadeDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.
Józef DulakDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland. jozef.dulak@uj.edu.pl.

Funding

Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney InjuryR01DK122986 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOLISETTY, SUBHASHINI · 2021 to 2025
$1.7M
National Agency of Academic Exchange NAWA grant PPN/ULM/2019/1/00304/U/00001NIDDK NIH HHS R01 DK122986NIH HHS R01DK122986Polish National Science Centre grant MAESTRO 2018/30/A/NZ3/00412
6 · The paper itself

Abstract

backgroundAdult muscle-resident myogenic stem cells, satellite cells (SCs), that play non-redundant role in muscle regeneration, are intrinsically impaired in Duchenne muscular dystrophy (DMD). Previously we revealed that dystrophic SCs express low level of anti-inflammatory and anti-oxidative heme oxygenase-1 (HO-1, HMOX1). Here we assess whether targeted induction of HMOX1 affect SC function and alleviates hallmark symptoms of DMD.

methodsWe generated double-transgenic mouse model (mdx;HMOX1

resultsHMOX1 induction caused a drop in SC pool in mdx;HMOX1

conclusionsTargeted expression of HMOX1 plays protective role in DMD and alleviates dystrophic muscle pathology.

Indexed as

Heme Oxygenase-1Mice, Inbred mdxMice, TransgenicMuscle, SkeletalMuscular Dystrophy, DuchenneSatellite Cells, Skeletal MuscleAnimalsMaleMembrane ProteinsMiceMice, Inbred C57BLPAX7 Transcription FactorPhysical Conditioning, AnimalHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsPax7 protein, mousePAX7 Transcription FactorDuchenne muscular dystrophyHeme oxygenase-1Satellite cellsSkeletal muscle regeneration

Identifiers

PMID38867250
PMCPMC11167827

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.