ArticleLipids in health and disease2024
Atherogenic Index of Plasma as a Mediator in the association between Body Roundness Index and Depression: insights from NHANES 2005-2018.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Decoding the lipid etiology of atherogenic index of plasma and gout: establishing the causal role of triglycerides through NHANES, Mendelian randomization, and network pharmacology.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Body roundness index mediates the association between high-density lipoprotein cholesterol and diabetic retinopathy: a population-based cross-sectional study.BMC endocrine disorders · 2026Article
- J-shaped association between body roundness index and depression: A large-scale cross-sectional study.Medicine · 2026Article
- Predictive value of the atherogenic index of plasma for incident hypertension in patients with obstructive sleep apnea.BMC pulmonary medicine · 2026Article
- Association of the atherogenic index of plasma and a novel triglyceride-glucose-body shape index with stroke: insights from NHANES and machine learning approaches.BMC cardiovascular disorders · 2026Article
- Threshold effects of atherogenic index of plasma on female infertility risk: evidence from NHANES 2013-2018.BMC women's health · 2025Article
- Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration.Cardiovascular diabetology · 2025Article
- The association between high atherogenic index of plasma and impaired lung function: a population-based study.Frontiers in medicine · 2025Article
- Article
- The mediating role of body roundness index in the association between dietary inflammatory index and depression: evidence from the US National Health and Nutrition Examination Survey 2007-2023.Frontiers in psychiatry · 2025Article
- High Body Roundness Index Is Associated With Unhealthy Sleep Patterns: Insights From NHANES (2007-2014).Brain and behavior · 2025Article
- Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma.Frontiers in psychiatry · 2025Article
- A comparative study of multiple physical assessment indicators to identify psychological symptoms: a cross-sectional study based on Chinese adolescents.Frontiers in nutrition · 2025Article
- Exploring the role of the atherogenic index of plasma as a mediator between body roundness Index and cardiovascular events in older adults: a NHANES-based study.Frontiers in cardiovascular medicine · 2025Article
- Association between cardiorenal syndrome and depressive symptoms among the US population: a mediation analysis via lipid indices.Lipids in health and disease · 2024Article
- Association between body roundness index and osteoarthritis: a cross-sectional analysis of NHANES 2011-2018.Frontiers in nutrition · 2024Article
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4 authors.
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Abstract
backgroundPrevious studies have shown a correlation between depression and obesity, as well as between depression and the Atherogenic Index of Plasma (AIP). However, there is limited research on the association between visceral obesity and depression, as well as the potential mediating role of AIP in this relationship.
methodsThis study included 13,123 participants from the 2005-2018 National Health and Nutrition Examination Survey. Visceral obesity was measured with the Body Roundness Index (BRI), while depression was evaluated with the Patient Health Questionnaire-9. The AIP served as a marker for lipid disorders. To investigate the association between the BRI and depression, multivariate logistic regressions, restricted cubic spline models, subgroup analyses, and interaction tests were used. Additionally, a mediation analysis was conducted to explore the role of AIP in mediating the effect of BRI on depression.
resultsThere was a positive linear correlation between the BRI and depression. After controlling for all covariates, individuals in the highest BRI (Q4) group had an OR of 1.42 for depression (95% CI: 1.12-1.82) in comparison with individuals in the lowest BRI (Q1) group. Moreover, the AIP partially mediated the association between the BRI and depression, accounting for approximately 8.64% (95% CI: 2.04-16.00%) of the total effect.
conclusionThe BRI was positively associated with depression, with the AIP playing a mediating role. This study provides a novel perspective on the mechanism that connects visceral obesity to depression. Managing visceral fat and monitoring AIP levels may contribute to alleviating depression.
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