ArticleNature2024
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of new-onset inflammatory bowel disease in psoriasis patients treated with five different interleukin inhibitors: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Mapping the global research landscape of risankizumab: a decade (2016-2025) of multi-database bibliometric analysis and emerging frontiers.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Multi-omics-driven precision medicine.iMeta · 2026Review
- Infection control in the brain and the eye.Acta ophthalmologica · 2026Review
- Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.Nature communications · 2026Article
- Impact of vitamin D plasma levels on in vitro natural killer cell cytotoxicity against non-small cell lung carcinoma in the presence of nivolumab.Internal and emergency medicine · 2026Article
- Review
- The roles and heterogeneity of CD8International journal of molecular medicine · 2026Review
- ILC2s and their immune checkpoints in the antitumor response.Journal for immunotherapy of cancer · 2026Review
- ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation.Mucosal immunology · 2026Article
- RORγtNature communications · 2026Article
- Acute peritonitis-induced adipose CD127Nature communications · 2026Article
- Liquiritin restores metabolic homeostasis in NAFLD by modulating AKT1/FOXO1 signaling.Frontiers in pharmacology · 2026Article
- Global Research Trends in Innate Lymphoid Cells in the Gut and Kidney: A Bibliometric and Visual Analysis.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Metabolic crosstalk between intestinal microbiota and dendritic cells: from homeostasis to inflammation.Acta biochimica et biophysica Sinica · 2025Review
- The Antigen Presenting Capabilities of Group 3 Innate Lymphoid Cells: Insights Into Immunogenic or Tolerogenic Outcomes for T Cells.European journal of immunology · 2025Review
- Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironment.Cellular & molecular immunology · 2025Article
- Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice.Nature communications · 2025Article
- Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Anees AhmedJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Ann M JosephJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jordan ZhouJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID 0000-0001-6047-9285
Veronika HornJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID 0000-0003-1439-5771
Jazib UddinJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID 0000-0001-5303-5213
Mengze LyuJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID 0000-0002-8509-7969
Jeremy GocJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID 0000-0002-4214-8877
JRI Live Cell Bank
Robbyn E SockolowDepartment of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Weill Cornell Medicine, Cornell University, New York, NY, USA.
James B WingLaboratory of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan.ORCID 0000-0002-3462-1003
Eric VivierInnate Pharma Research Laboratories, Innate Pharma, Marseille, France.ORCID 0000-0001-7022-8287
Shimon SakaguchiLaboratory of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan.ORCID 0000-0001-8265-6094
Gregory F SonnenbergJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology & Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA. gfsonnenberg@med.cornell.edu.ORCID 0000-0003-0948-5908
Funding
Regulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0MInterleukin-2 regulation of mucosal inflammationR01AI145989 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2019 to 2025
$5.3MImmune regulation of intestinal health and diseaseR01AI123368 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Gregory F Sonnenberg · 2016 to 2026
$3.6MInnate lymphoid cell regulation of the host-microbiota interactions in cancerR01CA274534 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2022 to 2025
$3.1MInnate immune regulation of neuroinflammationR01AI162936 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2021 to 2025
$3.1MNovel mechanisms protecting the gut from TNFR37AI174468 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Gregory F Sonnenberg · 2023 to 2026
$2.8MDefining a novel mechanism of mucosal healingR01AI143842 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2019 to 2023
$2.5MMultidisciplinary Research Training in Gastroenterology and HepatologyT32DK116970 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Randy S Longman · 2019 to 2026
$2.3MRegulation of Enteric Nervous System Function by Group 3 Innate Lymphoid CellsF32DK136248 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, JORDAN ZHENG · 2023 to 2025
$226kNCI NIH HHS R01 CA274534NIAID NIH HHS R01 AI123368NIAID NIH HHS R01 AI143842NIAID NIH HHS R01 AI145989NIAID NIH HHS R01 AI162936NIAID NIH HHS R37 AI174468NIAID NIH HHS U01 AI095608NIDDK NIH HHS F32 DK136248NIDDK NIH HHS T32 DK116970
Abstract
Interleukin (IL-)23 is a major mediator and therapeutic target in chronic inflammatory diseases that also elicits tissue protection in the intestine at homeostasis or following acute infection
Indexed as
Immunity, InnateInflammationInterleukin-23LymphocytesAnimalsB7-H1 AntigenCTLA-4 AntigenFemaleForkhead Box Protein O1Gastrointestinal MicrobiomeHumansInterleukin-23 Subunit p19IntestinesMaleMiceMice, Inbred C57BLB7-H1 AntigenCd274 protein, mouseCTLA-4 AntigenCTLA4 protein, humanCtla4 protein, mouseForkhead Box Protein O1Foxo1 protein, mouseIL23A protein, humanIl23a protein, mouseInterleukin-23Interleukin-23 Subunit p19Stat3 protein, mouseSTAT3 Transcription Factor
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.