ArticleCommunications biology2024
Genome-wide association and expression quantitative trait loci in cattle reveals common genes regulating mammalian fertility.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Bridging precision agriculture and human medicine through comparative genetics.Nature reviews. Genetics · 2026Review
- Integrating bulk and single-cell RNA sequencing with GWAS reveals regulatory networks underpinning complex traits in beef cattle.Journal of animal science and biotechnology · 2026Article
- Genetic Parameters and Weighted Single-Step Genome-Wide Association Studies of Fertility Traits in Chinese Holstein.Animals : an open access journal from MDPI · 2026Article
- Causal variants in animal genomes: approaches to identification, phenotypic impact, and implications for selective breeding.BMC genomics · 2026Review
- Functional Characterization of Long Non-Coding RNAs Associated with Reproductive Fitness in Pura Raza Española Mares.Animals : an open access journal from MDPI · 2026Article
- Vaginal Microbiome Is Associated with Breed and Pregnancy Status in Beef Cattle.Animals : an open access journal from MDPI · 2026Article
- Article
- Genome-wide association study identifies significant SNPs for milk production and stature traits in Karan Fries cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Opportunities and computational challenges in large-scale whole-genome sequencing data analysis.Journal of animal science · 2026Review
- Integrative analysis of GWAS, Bayesian fine-mapping, Mendelian randomization and colocalization reveals genetic determinants underlying milk-related traits in dairy cattle.Genetics, selection, evolution : GSE · 2026Article
- Multivariate Single-Step GWAS Reveals Pleiotropic Genomic Regions and Candidate Genes Associated with Male Scrotal Circumference and Female Fertility Traits in Retinta Beef Cattle.Veterinary sciences · 2025Article
- Selective sweeps for mutations increasing height impede identification of causative mutations for fertility and other correlated traits in cattle.Genetics, selection, evolution : GSE · 2025Article
- Involvement of chemokine CXCL12 and its receptor CXCR4 in uterine receptivity and potential relationship to fertility in cattle: a mini review.Frontiers in veterinary science · 2025Review
- Pangenome-genotyped structural variation improves molecular phenotype mapping in cattle.Genome research · 2024Article
- Mapping Expression Quantitative Trait Loci Targeting Candidate Genes for Pregnancy in Beef Cows.Biomolecules · 2024Article
- Harnessing Genomics and Transcriptomics Approaches to Improve Female Fertility in Beef Cattle-A Review.Animals : an open access journal from MDPI · 2023Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most genetic variants associated with fertility in mammals fall in non-coding regions of the genome and it is unclear how these variants affect fertility. Here we use genome-wide association summary statistics for Heifer puberty (pubertal or not at 600 days) from 27,707 Bos indicus, Bos taurus and crossbred cattle; multi-trait GWAS signals from 2119 indicine cattle for four fertility traits, including days to calving, age at first calving, pregnancy status, and foetus age in weeks (assessed by rectal palpation of the foetus); and expression quantitative trait locus for whole blood from 489 indicine cattle, to identify 87 putatively functional genes affecting cattle fertility. Our analysis reveals a significant overlap between the set of cattle and previously reported human fertility-related genes, impling the existence of a shared pool of genes that regulate fertility in mammals. These findings are crucial for developing approaches to improve fertility in cattle and potentially other mammals.
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