ArticleScientific reports2024
Decoding depression by exploring the exposome-genome edge amidst COVID-19 lockdown.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Illuminating the complex interplay of risk factors for depression symptoms within a large-scale US longitudinal cohort.Social psychiatry and psychiatric epidemiology · 2026Article
- The relationship between shyness and depression: the multiple mediating roles of sense of security and adaptability.Frontiers in psychology · 2026Article
- Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Risk of depression increased in the general population after the COVID-19 pandemic outbreak. By examining the interplay between genetics and individual environmental exposures during the COVID-19 lockdown, we have been able to gain an insight as to why some individuals are more vulnerable to depression, while others are more resilient. This study, conducted on a Spanish cohort of 9218 individuals (COVICAT), includes a comprehensive non-genetic risk analysis, the exposome, complemented by a genomics analysis in a subset of 2442 participants. Depression levels were evaluated using the Hospital Anxiety and Depression Scale. Together with Polygenic Risk Scores (PRS), we introduced a novel score; Poly-Environmental Risk Scores (PERS) for non-genetic risks to estimate the effect of each cumulative score and gene-environment interaction. We found significant positive associations for PERS
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Registered trials
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