Evidence map›Paper›PMID 38866860›Full record

Trial reportScientific reports2024

Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome.

Josefin Kataoka, Marie Olsson, Eva Lindgren, Ingrid Larsson, Johanna Schmidt, Anna Benrick, Elisabet Stener-Victorin

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01319162 (To Estimate the Prevalence of PCOS in Obese Premenopausal Women and Elucidate How They Respond to a Weight Reduction Treatment Program), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01319162 completednot on this map

To Estimate the Prevalence of PCOS in Obese Premenopausal Women and Elucidate How They Respond to a Weight Reduction Treatment Program

TypeobservationalSponsorGöteborg UniversityRan2011 to 2017Enrolled300ConditionsPolycystic Ovary SyndromeArmsWeight reduction regimen
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Josefin KataokaDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 430, 405 30, Gothenburg, Sweden.
Marie OlssonDepartment of Physiology and Pharmacology, Karolinska Institute, Biomedicum, B5, 171 77, Stockholm, Sweden.
Eva LindgrenDepartment of Physiology and Pharmacology, Karolinska Institute, Biomedicum, B5, 171 77, Stockholm, Sweden.
Ingrid LarssonDepartment of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Johanna SchmidtDepartment of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85, Gothenburg, Sweden.
Anna BenrickDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 430, 405 30, Gothenburg, Sweden.
Elisabet Stener-VictorinDepartment of Physiology and Pharmacology, Karolinska Institute, Biomedicum, B5, 171 77, Stockholm, Sweden. elisabet.stener-victorin@ki.se.

Funding

Adlerbertska Reseach Foundation AF2021-0105Diabetesfonden DIA2021-633Göteborgs Läkaresällskap Research grant for PhD-student GLS 961123KVVS 2021-525 and 2022-592Novo Nordisk Fonden NNF19OC0056647 and NNF22OC0072904Regional Agreement on Medical Training and Clinical Research between the Stockholm County Council and the Karolinska Institutet ALFMedN 20190079Vetenskapsrådet 2022-00550
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women that is associated with an increased risk of anxiety and depression and with a lower health-related quality of life (HRQoL). PCOS is closely associated with obesity, which per se can lead to symptoms of anxiety and depression and lower HRQoL. The first-line treatment for PCOS is weight loss through lifestyle intervention, which has been shown to improve all symptoms of the syndrome. The aim of this study was to investigate symptoms of anxiety and depression and HRQoL in women with severe obesity (BMI ≥ 35) with and without PCOS, and to evaluate the effect of a one-year structured weight loss intervention. A total of 246 women with severe obesity (PCOS n = 63, non-PCOS n = 183) were included. The comprehensive psychopathological rating scale self-rating scale for affective symptoms (CPRS-S-A) and the short form-36 (SF-36) were used to assess symptoms of anxiety and depression and HRQoL. In total 72 women of the 246 women with severe obesity completed a one-year weight loss programme and were followed up and compared with baseline data. In women with severe obesity, there were no differences in symptoms of anxiety and depression and HRQoL between women with and without PCOS at baseline. Clinically relevant anxiety symptoms were present in 71.3% (PCOS) and 65.6% (non-PCOS), and depression symptoms were present in 56.4% (PCOS) and 52.2% (non-PCOS). Significant weight loss improved physical HRQoL in all women, but reduced symptoms of anxiety and depression only in women without PCOS. There were no differences when comparing the changes between the groups. Women with severe obesity are severely affected by symptoms of anxiety and depression, independent of PCOS. Weight loss improved symptoms of anxiety and depression in women without PCOS, but there were no differences between groups in change from baseline to follow-up.Trial registration number: Clinical trial.gov: NCT01319162, March 18, 2011. Date of registration and enrolment of the first subject September 2011.

Indexed as

AnxietyDepressionPolycystic Ovary SyndromeQuality of LifeWeight LossAdultFemaleHumansObesity, MorbidWeight Reduction ProgramsAnxietyDepressionHealth-related quality of lifePolycystic ovary syndromeSevere obesityWeight loss

Identifiers

PMID38866860
PMCPMC11169487

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.