Evidence map›Paper›PMID 38866722›Full record

ReviewChemPlusChem2024

Towards Synthetic Cells with Self-Producing Energy.

Sung-Won Hwang, Minha Kim, Allen P Liu

Abstract readReview
In one paragraph

Review in ChemPlusChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Photocatalytic Biohybrid Vesicles.Chemical reviews · 2026
    Review
  4. Stimuli-Responsive Chemical Systems That Mimic Biological Dynamics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  5. ATP-Powered Signaling Between Artificial and Living Cells.Angewandte Chemie (International ed. in English) · 2025
    Article
  6. Building a Synthetic Cell Together.Nature communications · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sung-Won HwangDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1686-7090
Minha KimDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Allen P LiuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0309-7018

Funding

Development of a mechanosensitive synthetic cell for mediating intercellular communication - Diversity SupplementR01EB030031 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, ALLEN PO-CHIH · 2020 to 2024
$1.3M
Mechanosensitive synthetic cell-regulatable hydrogels for tissue engineeringR21AR080363 · NIAMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALSBERG, EBEN, LIU, ALLEN PO-CHIH · 2022 to 2023
$384k
Shear stress-activated synthetic cells for targeted drug release in stenotic blood vesselsF31HL170510 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HWANG, SUNG-WON · 2023 to 2024
$84k
National Institutes of Health Ruth L. Kirschstein Predoctoral Fellowship 1F31HL170510National Science Foundation EF1935265NHLBI NIH HHS F31 HL170510NIAMS NIH HHS R21 AR080363NIBIB NIH HHS R01 EB030031NIH HHS AR080363NIH HHS EB030031
6 · The paper itself

Abstract

Autonomous generation of energy, specifically adenosine triphosphate (ATP), is critical for sustaining the engineered functionalities of synthetic cells constructed from the bottom-up. In this mini-review, we categorize studies on ATP-producing synthetic cells into three different approaches: photosynthetic mechanisms, mitochondrial respiration mimicry, and utilization of non-conventional approaches such as exploiting synthetic metabolic pathways. Within this framework, we evaluate the strengths and limitations of each approach and provide directions for future research endeavors. We also introduce a concept of building ATP-generating synthetic organelle that will enable us to mimic cellular respiration in a simpler way than current strategies. This review aims to highlight the importance of energy self-production in synthetic cells, providing suggestions and ideas that may help overcome some longstanding challenges in this field.

Indexed as

Adenosine TriphosphateArtificial CellsEnergy MetabolismMitochondriaPhotosynthesisAdenosine TriphosphateATP synthesisEnergy self-productionSynthetic cellSynthetic organelle

Identifiers

PMID38866722
PMCPMC11726215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.