Evidence map›Paper›PMID 38866555›Full record

ArticleGenes & development2024

A nuclear architecture screen in

Ankita Chavan, Randi Isenhart, Son C Nguyen, Noor M Kotb, Jailynn Harke, Anna Sintsova, Gulay Ulukaya, Federico Uliana, Caroline Ashiono, Ulrike Kutay and 4 more

Abstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ankita Chavan *Institute of Biochemistry, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich 8093, Switzerland.
Randi Isenhart *Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Son C NguyenPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Noor M KotbDepartment of Cell, Developmental, and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Jailynn HarkePenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Anna SintsovaInstitute of Microbiology, Department of Biology, ETH Zürich, Zürich 8093, Switzerland.
Gulay UlukayaBioinformatics for Next-Generation Sequencing (BiNGS) Core, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Federico UlianaInstitute of Biochemistry, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich 8093, Switzerland.
Caroline AshionoInstitute of Biochemistry, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich 8093, Switzerland.
Ulrike KutayInstitute of Biochemistry, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich 8093, Switzerland.
Gianluca PegoraroHigh-Throughput Imaging Facility (HiTIF), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID 0000-0003-2843-9464
Prashanth RanganDepartment of Cell, Developmental, and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Eric F JoycePenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; madhav.jagannathan@bc.biol.ethz.ch erjoyce@pennmedicine.upenn.edu.
Madhav JagannathanInstitute of Biochemistry, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich 8093, Switzerland; madhav.jagannathan@bc.biol.ethz.ch erjoyce@pennmedicine.upenn.edu.ORCID 0000-0003-3428-6812

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
HiTIF Microscopy Core FacilityZICBC011567 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PEGORARO, GIANLUCA · 2014 to 2025
$15.8M
Engineering and Imaging 3D genome structure-function dynamics across time scalesU01DK127405 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BLOBEL, GERD A, PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2020 to 2024
$5.7M
Regulation of chromatin folding in space and timeR35GM128903 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Eric F. Joyce · 2018 to 2026
$4.2M
Single-cell dissection of chromatin architecture mechanisms connecting pathologic instability and transcriptional silencingU01DA052715 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN, JOYCE, ERIC F. · 2020 to 2024
$3.1M
Regulation of stem cell differentiation during Drosophila oogenesisR01GM111779 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI RANGAN, PRASHANTH · 2014 to 2022
$2.7M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Role of RNA degradation in germline stem cell to oocyte transitionR01GM135628 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI RANGAN, PRASHANTH · 2020 to 2023
$1.3M
Evaluating novel architectural proteins as therapeutic targets for cohesin dysfunctionR21HD107261 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI JOYCE, ERIC F. · 2022 to 2023
$447k
Cellular rejuvenation during oogenesisR56AG082906 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAPELSON, MAYA, RANGAN, PRASHANTH · 2023 to 2023
$387k
NCATS NIH HHS UL1 TR004419NCI NIH HHS P30 CA196521NIA NIH HHS R56 AG082906NICHD NIH HHS R21 HD107261NIDA NIH HHS U01 DA052715NIDDK NIH HHS U01 DK127405NIGMS NIH HHS R01 GM111779NIGMS NIH HHS R01 GM135628NIGMS NIH HHS R35 GM128903NIH HHS S10 OD026880
6 · The paper itself

Abstract

The association of genomic loci to the nuclear periphery is proposed to facilitate cell type-specific gene repression and influence cell fate decisions. However, the interplay between gene position and expression remains incompletely understood, in part because the proteins that position genomic loci at the nuclear periphery remain unidentified. Here, we used an Oligopaint-based HiDRO screen targeting ∼1000 genes to discover novel regulators of nuclear architecture in

Indexed as

Cell DifferentiationCell NucleusChromatinDrosophila ProteinsAnimalsDrosophilaDrosophila melanogasterFemaleGene Expression Regulation, DevelopmentalGerm CellsStem CellsChromatinDrosophila Proteinsgenome organizationgermline stem cellheterochromatinnuclear architecturenuclear periphery

Identifiers

PMID38866555
PMCPMC11216176

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.