Evidence map›Paper›PMID 38866499›Full record

ArticleeNeuro2024

Loss of Sigma-2 Receptor/TMEM97 Is Associated with Neuropathic Injury-Induced Depression-Like Behaviors in Female Mice.

Veronica M Hong, Avaneesh D Rade, Shen M Yan, Amulya Bhaskara, Muhammad Saad Yousuf, Min Chen, Stephen F Martin, Daniel J Liebl, Theodore J Price, Benedict J Kolber

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Veronica M HongDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080.
Avaneesh D RadeDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080.
Shen M YanDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080.
Amulya BhaskaraDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080.
Muhammad Saad YousufDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080.
Min ChenDepartment of Mathematical Sciences, School of Natural Sciences and Mathematics, University of Texas at Dallas, Richardson, Texas 75080.
Stephen F MartinDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712.
Daniel J LieblDepartment of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida 33146.
Theodore J PriceDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080.ORCID https://orcid.org/0000-0002-6971-6221
Benedict J KolberDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080 benedict.kolber@utdallas.edu.ORCID https://orcid.org/0000-0001-8665-1805

Funding

Impact of Amygdala Lateralization on Processing and Modulation of Bladder PainR01DK115478 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI BENEDICT J KOLBER · 2018 to 2026
$4.3M
Planning Study for the Development of Sigma 2 ligands as AnalgesicsR61NS127271 · NINDS · UNIVERSITY OF KENTUCKY · PI KOLBER, BENEDICT J, TIDGEWELL, KEVIN JOSEPH · 2023 to 2023
$1.5M
Sigma 2 Receptor (TMEM97): Investigating the Peripheral Role of this Novel Therapeutic Target for PainF31NS129269 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI HONG, VERONICA MINSU · 2023 to 2025
$130k
NIDDK NIH HHS R01 DK115478NINDS NIH HHS F31 NS129269NINDS NIH HHS R61 NS127271
6 · The paper itself

Abstract

Previous studies have shown that ligands that bind to sigma-2 receptor/TMEM97 (s

Indexed as

DepressionMembrane ProteinsMice, Inbred C57BLMice, KnockoutNeuralgiaReceptors, sigmaAnimalsAnxietyBehavior, AnimalDisease Models, AnimalFemaleMiceMembrane ProteinsReceptors, sigmasigma-2 receptoranxiety and depressionbehaviorspainsigma-2 receptor/TMEM97

Identifiers

PMID38866499
PMCPMC11228697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.