Evidence map›Paper›PMID 38865681›Full record

ArticleNeurology2024

Lifetime History of Low Birth Weight Delivery and Cognitive Function in Middle-Aged Parous Women.

Diana C Soria-Contreras, Jiaxuan Liu, Rebecca B Lawn, Siwen Wang, Alexandra Purdue-Smithe, Francine Grodstein, Emily Oken, Jorge E Chavarro

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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Diana C Soria-ContrerasFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.ORCID 0000-0001-5783-5365
Jiaxuan LiuFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.
Rebecca B LawnFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.
Siwen WangFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.
Alexandra Purdue-SmitheFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.
Francine GrodsteinFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.ORCID 0000-0002-2699-7051
Emily OkenFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.
Jorge E ChavarroFrom the Departments of Nutrition (D.C.S.-C., S.W., E.O., J.E.C.) and Epidemiology (J.L., R.B.L., J.E.C.), Harvard T.H. Chan School of Public Health, Boston; Division of Women's Health (A.P.-S.) and Channing Division of Network Medicine, Department of Medicine (J.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine (E.O.), Harvard Medical School, Boston; and Harvard Pilgrim Health Care Institute (E.O.), Boston, MA.

Funding

Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Post Traumatic Stress Disorder and Accelerated Aging in WomenR01MH101269 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI KOENEN, KARESTAN C, KUBZANSKY, LAURA D · 2014 to 2021
$6.5M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
The Training Program in Reproductive, Perinatal, and Pediatric Life Course EpidemiologyT32HD104612 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sonia Hernandez-Diaz, Henning Tiemeier · 2021 to 2026
$2.2M
DIET, PHYSICAL ACTIVITY, AND THE RELATIONSHIP BETWEEN AIR POLLUTION AND CVDR01ES017017 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI LADEN, FRANCINE · 2009 to 2012
$1.7M
Posttraumatic Stress Disorder and Cognitive Decline in WomenR21MH102570 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI GRODSTEIN, FRANCINE, KOENEN, KARESTAN C · 2014 to 2015
$490k
NHLBI NIH HHS U01 HL145386NICHD NIH HHS T32 HD104612NIEHS NIH HHS R01 ES017017NIEHS NIH HHS R01 ES028033NIMH NIH HHS R01 MH101269NIMH NIH HHS R21 MH102570
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPregnancy outcomes such as low birth weight (LBW) delivery may reflect vascular or metabolic dysfunction in mothers and presage future cognitive impairment and dementia. However, the evidence is currently limited. Our objective was to examine the extent to which a lifetime history of LBW delivery was associated with cognitive function in parous middle-aged women.

methodsWe studied participants from the Nurses' Health Study II, an ongoing longitudinal cohort of female nurses enrolled in 1989. In 2009, participants completed a reproductive history questionnaire. Participants who completed at least one of 2 post-traumatic stress disorder questionnaires were invited to participate in a cognition substudy with 2 waves of baseline data collection (2014 or 2018). We restricted the analysis to participants with one valid cognitive assessment who reported ≥1 birth at 18 years and older. We defined LBW delivery history as having delivered offspring with a birth weight <2,500 g (<5.5 lbs) in any pregnancy. The outcome was a single assessment of cognitive function evaluated with the self-administered Cogstate Brief Battery. The battery comprises 4 tasks, which we used to create 2 composite z-scores measuring psychomotor speed/attention and learning/working memory (higher z-scores = better cognitive function). We used multivariable linear regression models.

resultsThe analysis included 15,323 participants with a mean age of 62 (standard deviation: 4.9 years) at cognitive assessment. Among them, 1,224 (8%) had a history of LBW delivery. After adjusting for age at cognitive assessment, race, and ethnicity, participants' education, wave of baseline cognitive assessment, socioeconomic status, and prepregnancy characteristics, women with a history of LBW delivery had lower z-scores in the psychomotor speed/attention (β, -0.06; 95% CI -0.12 to -0.01) and learning/working memory (β, -0.05; 95% CI -0.09 to -0.01) composites than parous women without a history of LBW delivery. We observed a gradient of lower z-scores with an increasing number of LBW deliveries. DISCUSSION: History of LBW delivery may be marker of future poorer cognition. If confirmed, our findings support future investigations into the value of early preventive efforts targeting women with a history of LBW delivery to reduce the burden of cognitive impairment in women.

Indexed as

CognitionInfant, Low Birth WeightAdultCognitive DysfunctionCohort StudiesFemaleHumansLongitudinal StudiesMiddle AgedNeuropsychological TestsPregnancy

Identifiers

PMID38865681
PMCPMC12334342

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