ArticleScience advances2024
Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed.
- Habitat-Specific Design Strategies for Untethered Soft Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biomimetic and personalized nanovaccines in cancer immunotherapy: Design innovations, translational challenges, and future directions.Journal of advanced research · 2026Review
- Micro/Nanorobots (MNRs) at the Intersection of Mechanobiology and Artificial Intelligence: An Emerging Frontier for Precision Nanomedicine.ACS nano medicine · 2026Review
- Structural Evolution of Biomedical Microrobots: From Rigid to Soft to Rigid-Soft Integrated Systems.Gels (Basel, Switzerland) · 2026Review
- Task-Oriented Biomedical Microrobots: Access, Working Environment, Actuation, Body Design, Detection and Control.Micromachines · 2026Review
- Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling.Thoracic cancer · 2026Article
- Multistage microrobots with pH-responsive release of platelet membrane-coated nanoparticles.Science advances · 2026Article
- Phototaxis and Motility ofMicromachines · 2026Article
- Chemotactic Gold Nanozyme-Powered Flasklike Pentosan Nanobots for Tumor-Specific Drug Delivery.Advanced healthcare materials · 2026Article
- Acceleration of DNA reactions on the algae-based microrobots.Journal of nanobiotechnology · 2026Article
- Deployment and clearance of microrobots for localized therapy: past, present and future.National science review · 2026Review
- An inhalable microbe-oncolytic virus consortium for lung cancer treatment.Cell reports. Medicine · 2026Article
- Magnetic medical microrobots with memory-capable genetic circuits.Science advances · 2026Article
- Targeting Cancers with Microrobots and Bacteriobots.Molecular biotechnology · 2026Review
- Machine learning-driven design of engineered cilia enables hybrid operations in acoustic microrobots.Nature communications · 2026Article
- Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management.Nature communications · 2026Article
- Embodied Cross-Domain Intelligence in Biomedical Microrobots: A Review.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Autonomous Microrobots for Spatiotemporally Active Therapeutic Delivery and Controlled Release.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Light Metabolically Reprograms CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microsystem technologies for accelerating the discovery and translation of immunotherapies.Nature reviews. Drug discovery · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Lung metastasis poses a formidable challenge in the realm of cancer treatment, with conventional chemotherapy often falling short due to limited targeting and low accumulation in the lungs. Here, we show a microrobot approach using motile algae for localized delivery of drug-loaded nanoparticles to address lung metastasis challenges. The biohybrid microrobot [denoted "algae-NP(DOX)-robot"] combines green microalgae with red blood cell membrane-coated nanoparticles containing doxorubicin, a representative chemotherapeutic drug. Microalgae provide autonomous propulsion in the lungs, leveraging controlled drug release and enhanced drug dispersion to exert antimetastatic effects. Upon intratracheal administration, algae-NP(DOX)-robots efficiently transport their drug payload deep into the lungs while maintaining continuous motility. This strategy leads to rapid drug distribution, improved tissue accumulation, and prolonged retention compared to passive drug-loaded nanoparticles and free drug controls. In a melanoma lung metastasis model, algae-NP(DOX)-robots exhibit substantial improvement in therapeutic efficacy, reducing metastatic burden and extending survival compared to control groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.