Evidence map›Paper›PMID 38865457›Full record

ArticleScience advances2024

Cofactor maturase NifEN: A prototype ancient nitrogenase?

Chi Chung Lee, Kamil Górecki, Martin Stang, Markus W Ribbe, Yilin Hu

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Minimal ATP-Independent NAngewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. NifEN: a versatile player in nitrogenase assembly, catalysis and evolution.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chi Chung LeeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697- 3900, USA.ORCID 0000-0002-5266-6686
Kamil GóreckiDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697- 3900, USA.ORCID 0000-0002-9672-2408
Martin StangDepartment of Chemistry, University of California, Irvine, CA 92697-2025, USA.ORCID 0000-0002-0781-8097
Markus W RibbeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697- 3900, USA.ORCID 0000-0002-7366-1526
Yilin HuDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697- 3900, USA.ORCID 0000-0002-9088-2865

Funding

Nitrogenase Assembly MechanismR01GM067626 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI RIBBE, MARKUS W · 2003 to 2024
$6.3M
Probing a novel reaction mechanism of nitrogenase with dynamic active-site rearrangementsR01GM141046 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HU, YILIN · 2021 to 2024
$1.3M
NIGMS NIH HHS R01 GM067626NIGMS NIH HHS R01 GM141046
6 · The paper itself

Abstract

Nitrogenase plays a key role in the global nitrogen cycle; yet, the evolutionary history of nitrogenase and, particularly, the sequence of appearance between the homologous, yet distinct NifDK (the catalytic component) and NifEN (the cofactor maturase) of the extant molybdenum nitrogenase, remains elusive. Here, we report the ability of NifEN to reduce N

Indexed as

NitrogenaseBacterial ProteinsModels, MolecularMolybdoferredoxinNitrogenNitrogen FixationPhylogenyBacterial ProteinsMolybdoferredoxinNitrogenNitrogenase

Identifiers

PMID38865457
PMCPMC11168457

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.