Evidence map›Paper›PMID 38865349›Full record

ArticleBioconjugate chemistry2024

Photocontrolled Reversible Amyloid Fibril Formation of Parathyroid Hormone-Derived Peptides.

André Paschold, Moritz Schäffler, Xincheng Miao, Luis Gardon, Stephanie Krüger, Henrike Heise, Merle I S Röhr, Maria Ott, Birgit Strodel, Wolfgang H Binder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

André PascholdMacromolecular Chemistry, Institute of Chemistry, Faculty of Natural Science II, Martin Luther University Halle Wittenberg, von-Danckelmann-Platz 4, Halle 06120, Germany.
Moritz SchäfflerInstitute of Theoretical and Computational Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.
Xincheng MiaoCenter for Nanosystems Chemistry (CNC), Theodor-Boveri Weg, Universität Würzburg, Würzburg 97074, Germany.
Luis GardonInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich 52425, Germany.
Stephanie KrügerBiozentrum, Martin Luther University Halle-Wittenberg, Weinberweg 22, Halle 06120, Germany.
Henrike HeiseInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich 52425, Germany.ORCID 0000-0002-9081-3894
Merle I S RöhrCenter for Nanosystems Chemistry (CNC), Theodor-Boveri Weg, Universität Würzburg, Würzburg 97074, Germany.ORCID 0000-0002-2128-3498
Maria OttInstitute of Biophysics, Faculty of Natural Science I, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3, Halle 06120, Germany.ORCID 0000-0002-4686-9516
Birgit StrodelInstitute of Theoretical and Computational Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.ORCID 0000-0002-8734-7765
Wolfgang H BinderMacromolecular Chemistry, Institute of Chemistry, Faculty of Natural Science II, Martin Luther University Halle Wittenberg, von-Danckelmann-Platz 4, Halle 06120, Germany.ORCID 0000-0003-3834-5445

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide fibrillization is crucial in biological processes such as amyloid-related diseases and hormone storage, involving complex transitions between folded, unfolded, and aggregated states. We here employ light to induce reversible transitions between aggregated and nonaggregated states of a peptide, linked to the parathyroid hormone (PTH). The artificial light-switch 3-{[(4-aminomethyl)phenyl]diazenyl}benzoic acid (AMPB) is embedded into a segment of PTH, the peptide PTH

Indexed as

AmyloidParathyroid HormoneHumansLightPeptide FragmentsPeptidesPhotochemical ProcessesProtein AggregatesAmyloidParathyroid HormonePeptide FragmentsPeptidesProtein Aggregates

Identifiers

PMID38865349
PMCPMC11261605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.