Evidence map›Paper›PMID 38865277›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Temporal control of RNAi reveals both robust and labile feedback loops in the segmentation clock of the red flour beetle.

Felix Kaufholz, Julia Ulrich, Muhammad Salim Hakeemi, Gregor Bucher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Felix Kaufholz *Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, Göttingen 37077, Germany.ORCID 0000-0002-1402-2628
Julia Ulrich *Department of Evolutionary Developmental Genetics, University of Göttingen, Johann-Friedrich-Blumenbach Institute, Göttingen Center for Molecular Biosciences, Göttingen 37077, Germany.
Muhammad Salim HakeemiDepartment of Evolutionary Developmental Genetics, University of Göttingen, Johann-Friedrich-Blumenbach Institute, Göttingen Center for Molecular Biosciences, Göttingen 37077, Germany.
Gregor BucherDepartment of Evolutionary Developmental Genetics, University of Göttingen, Johann-Friedrich-Blumenbach Institute, Göttingen Center for Molecular Biosciences, Göttingen 37077, Germany.ORCID 0000-0002-4615-6401

Funding

Deutsche Forschungsgemeinschaft (DFG) BU1443/14-1Deutsche Forschungsgemeinschaft (DFG) BU1443/14-1ad
6 · The paper itself

Abstract

Animals from all major clades have evolved a segmented trunk, reflected in the human spine or the insect segments. These units emerge during embryogenesis from a posterior segment addition zone (SAZ), where repetitive gene activity is regulated by a mechanism described by the clock and wavefront/speed gradient model. In the red flour beetle

Indexed as

Body PatterningRNA InterferenceTriboliumAnimalsAnimals, Genetically ModifiedBiological ClocksFeedback, PhysiologicalGene Expression Regulation, Developmentalclock and wavefrontinsect segmentationRNAisegmentation breakdowntransgenic tool

Identifiers

PMID38865277
PMCPMC11194489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.