Evidence map›Paper›PMID 38865270›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation-contraction coupling in ventricular myocytes.

Paula Rhana, Collin Matsumoto, Zhihui Fong, Alexandre D Costa, Silvia G Del Villar, Rose E Dixon, L Fernando Santana

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Small-conductance CaThe Journal of physiology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Biomarkers of Cardiac Metabolic Flexibility in Health, HFrEF and HFpEF.International journal of molecular sciences · 2026
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Bat power-metabolic profiling of the Egyptian fruit batbioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Paula RhanaDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-6065-2903
Collin MatsumotoDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-5370-1156
Zhihui FongDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
Alexandre D CostaDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-4470-8225
Silvia G Del VillarDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-5612-4761
Rose E DixonDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0003-0655-690X
L Fernando SantanaDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-4297-8029

Funding

Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
Molecular choreography of CaV1.2 channels in the aging myocardiumR01AG063796 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Rose Ellen Dixon · 2019 to 2026
$3.1M
Lipid regulation of Cardiac Excitation-Contraction couplingR01HL159304 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIXON, ROSE ELLEN · 2022 to 2025
$2.4M
HHS | National Institutes of Health (NIH) OT2OD026580HHS | National Institutes of Health (NIH) R01AG063796HHS | National Institutes of Health (NIH) R01HL159304NHLBI NIH HHS R01 HL159304NIA NIH HHS R01 AG063796NIH HHS OT2 OD026580
6 · The paper itself

Abstract

The heart beats approximately 100,000 times per day in humans, imposing substantial energetic demands on cardiac muscle. Adenosine triphosphate (ATP) is an essential energy source for normal function of cardiac muscle during each beat, as it powers ion transport, intracellular Ca

Indexed as

Adenosine TriphosphateCalciumExcitation Contraction CouplingHeart VentriclesMyocytes, CardiacAction PotentialsAnimalsHeart RateHumansKATP ChannelsMiceMyocardial ContractionSarcoplasmic ReticulumAdenosine TriphosphateCalciumKATP Channelscalciumelectrometabolic couplingmitochondriamitofusin 2

Identifiers

PMID38865270
PMCPMC11194497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.