Evidence map›Paper›PMID 38864916›Full record

ArticleAnalytical and bioanalytical chemistry2024

Raspberry-shaped ZIF-8/Au nanozymes with excellent peroxidase-like activity for simple and visual detection of glutathione.

Zhentong Zhu, Xiaoli Wang, Na Wang, Chaoqin Zeng, Lei Zhang, Jiamin Fan, Xin Yang, Peizhe Li, Hongxia Yuan, Yanjun Feng and 2 more

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhentong ZhuKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China. zhtzhu@nwnu.edu.cn.
Xiaoli WangKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Na WangKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Chaoqin ZengKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Lei ZhangKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Jiamin FanKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Xin YangKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Peizhe LiKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Hongxia YuanGansu Provincial Academic Institute for Medical Research, Lanzhou, 730070, People's Republic of China.
Yanjun FengKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Shuhui HuoKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
Xiaoquan LuKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China. luxq@nwnu.edu.cn.

Funding

Industrial support plan of Gansu Provincial Department of Education (2021cyzc-01)Key Research and Development Program of Gansu Province (23YFGA0082)National Natural Science Foundation of China 22004102National Natural Science Foundation of China 22066021)National Natural Science Foundation of China (22127803National Natural Science Foundation of China 22174110Science Fund for Distinguished Young Scholars of Gansu Province (21JR7RA157)Scientific and Technological Innovation Talents of Gansu Province (22JR9KA031).Scientific Research Ability Improvement Program of Northwest Normal University (NWNU-LKQN2020-03)West Light Foundation of the Chinese Academy of Sciences (2021)
6 · The paper itself

Abstract

Artificial enzymes with high stability, adjustable catalytic activity, controllable preparation, and good reproducibility have been widely studied. Noble metal nanozymes, particularly gold nanoparticles (Au NPs), exhibit good catalytic activity, but their stability is poor. In this study, zeolitic imidazolate framework-8 (ZIF-8) was used as a carrier for Au NPs, thus improving the utilization efficiency and conservation stability of the nanozymes. A ZIF-8/Au nanocomposite with peroxidase activity and a raspberry-shaped structure was synthesized. In the assay, ZIF-8/Au catalyzed the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to a blue product oxidized TMB (oxTMB). Glutathione (GSH) selectively inhibited this reaction, with a detection limit of 0.28 µM and linear range of 0.5-60 µM. Using the photo and chromaticity analysis functions, we developed a portable analysis method using a smartphone equipped with a camera module as a detection terminal for a wide range of rapid screening techniques for GSH. Preparation of raspberry-shaped ZIF-8/Au improved the catalytic activity of Au NPs and good results were demonstrated in serum, which suggests their promising application under physiological conditions.

Indexed as

GlutathioneGoldLimit of DetectionMetal NanoparticlesBenzidinesCatalysisColorimetryHumansMetal-Organic FrameworksOxidation-ReductionPeroxidaseSmartphoneZeolites3,3',5,5'-tetramethylbenzidineBenzidinesGlutathioneGoldMetal-Organic FrameworksPeroxidaseZeolites3,3′,5,5′-Tetramethylbenzidine (TMB)Colourimetric sensingNanozymesPeroxidase-like enzyme

Identifiers

PMID38864916

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.